The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{11 , 12} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{13 , 14} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.¹⁵ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,¹⁶ but not all,¹⁷ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.¹⁸

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.¹⁹ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{20 , 21}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.²²

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{23 , 24} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{25 , 26} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.²⁷ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,²⁸ but not all,²⁹ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.³⁰

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.³¹ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{32 , 33}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.³⁴

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{35 , 36} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{37 , 38} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.³⁹ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,⁴⁰ but not all,⁴¹ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.⁴²

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.⁴³ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{44 , 45}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.⁴⁶

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{47 , 48} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{49 , 50} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.⁵¹ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,⁵² but not all,⁵³ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.⁵⁴

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.⁵⁵ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{56 , 57}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.⁵⁸

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{59 , 60} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{61 , 62} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.⁶³ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,⁶⁴ but not all,⁶⁵ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.⁶⁶

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.⁶⁷ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{68 , 69}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.⁷⁰

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{71 , 72} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{73 , 74} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.⁷⁵ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,⁷⁶ but not all,⁷⁷ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.⁷⁸

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.⁷⁹ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{80 , 81}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.⁸²

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{83 , 84} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{85 , 86} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.⁸⁷ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,⁸⁸ but not all,⁸⁹ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.⁹⁰

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.⁹¹ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{92 , 93}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.⁹⁴

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{95 , 96} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{97 , 98} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.⁹⁹ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,¹⁰⁰ but not all¹⁰¹ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.¹⁰²

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.¹⁰³ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{104 , 105}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.¹⁰⁶

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{107 , 108} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{109 , 110} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.¹¹¹ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,¹¹² but not all,¹¹³ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.¹¹⁴

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.¹¹⁵ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{116 , 117}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.¹¹⁸

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{119 , 120} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{121 , 122} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.¹²³ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,¹²⁴ but not all¹²⁵ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.¹²⁶

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.¹²⁷ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{128 , 129}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.¹³⁰

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{131 , 132} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{133 , 134} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.¹³⁵ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,¹³⁶ but not all,¹³⁷ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.¹³⁸

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.¹³⁹ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{140 , 141}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.¹⁴²

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{143 , 144} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{145 , 146} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.¹⁴⁷ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,¹⁴⁸ but not all,¹⁴⁹ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.¹⁵⁰

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.¹⁵¹ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{152 , 153}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.¹⁵⁴

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{155 , 156} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{157 , 158} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.¹⁵⁹ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,¹⁶⁰ but not all,¹⁶¹ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.¹⁶²

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.¹⁶³ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{164 , 165}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.¹⁶⁶

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{167 , 168} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{169 , 170} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.¹⁷¹ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,¹⁷² but not all,¹⁷³ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.¹⁷⁴

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.¹⁷⁵ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{176 , 177}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.¹⁷⁸

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{179 , 180} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{181 , 182} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.¹⁸³ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,¹⁸⁴ but not all¹⁸⁵ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.¹⁸⁶

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.¹⁸⁷ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{188 , 189}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.¹⁹⁰

In a double-blind study, supplementation with 18 grams of glutamine per day for 15 days, starting five days before the beginning of 5-FU therapy, significantly reduced the severity of drug-induced intestinal toxicity.¹⁹¹

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.¹⁹²

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{193 , 194} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{195 , 196} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.¹⁹⁷ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,¹⁹⁸ but not all,¹⁹⁹ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.²⁰⁰

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.²⁰¹ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{202 , 203}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.²⁰⁴

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{205 , 206} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{207 , 208} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.²⁰⁹ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,²¹⁰ but not all,²¹¹ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.²¹²

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.²¹³ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{214 , 215}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.²¹⁶

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{217 , 218} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{219 , 220} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.²²¹ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,²²² but not all,²²³ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.²²⁴

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.²²⁵ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{226 , 227}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.²²⁸

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{241 , 242} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{243 , 244} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.²⁴⁵ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,²⁴⁶ but not all,²⁴⁷ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.²⁴⁸

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.²⁴⁹ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{250 , 251}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.²⁵²

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{253 , 254} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{255 , 256} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.²⁵⁷ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,²⁵⁸ but not all,²⁵⁹ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.²⁶⁰

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.²⁶¹ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{262 , 263}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.²⁶⁴

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{265 , 266} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{267 , 268} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.²⁶⁹ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,²⁷⁰ but not all,²⁷¹ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.²⁷²

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.²⁷³ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{274 , 275}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.²⁷⁶

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{277 , 278} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{279 , 280} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.²⁸¹ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,²⁸² but not all²⁸³ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.²⁸⁴ In another preliminary trial, supplementation with 10 grams of glutamine three times per day, beginning 24 hours after administration of high-dose paclitaxel, reduced the severity of drug-induced nerve damage (peripheral neuropathy).²⁸⁵

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.²⁸⁶ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{287 , 288}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.²⁸⁹

Paclitaxel commonly causes muscle and joint pain. Five cases of people experiencing these symptoms who responded to the amino acid glutamine have been reported.²⁹⁰ All five were given 10 grams glutamine by mouth three times per day beginning 24 hours after the paclitaxel treatment. Although the report does not state how many days glutamine supplements were taken, it may have been for ten days or less—the typical time it takes for these symptoms to subside following paclitaxel administration. Whereas all five had experienced moderate to severe symptoms from the drug when taken previously without glutamine, none of the five experienced these symptoms when glutamine was added. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 g of glutamine four times daily along with the chemotherapy.²⁹¹

Glutamate, an amino acid structurally related to glutamine, had previously been reported to reduce paclitaxel-induced nerve damage in animals.²⁹²

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{293 , 294} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{295 , 296} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.²⁹⁷ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,²⁹⁸ but not all,²⁹⁹ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.³⁰⁰

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.³⁰¹ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{302 , 303}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.³⁰⁴

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{305 , 306} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{307 , 308} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.³⁰⁹ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,³¹⁰ but not all,³¹¹ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.³¹²

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.³¹³ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{314 , 315}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.³¹⁶

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{317 , 318} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{319 , 320} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.³²¹ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,³²² but not all,³²³ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.³²⁴

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.³²⁵ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{326 , 327}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.³²⁸

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{329 , 330} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{331 , 332} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.³³³ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,³³⁴ but not all,³³⁵ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.³³⁶

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.³³⁷ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{338 , 339}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.³⁴⁰

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{341 , 342} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{343 , 344} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.³⁴⁵ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,³⁴⁶ but not all,³⁴⁷ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.³⁴⁸

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.³⁴⁹ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{350 , 351}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.³⁵²

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.^{229 , 230} In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy,^{231 , 232} though such effects have not yet been studied in humans.

Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day.²³³ Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some,²³⁴ but not all,²³⁵ double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.²³⁶

One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy.²³⁷ However, other studies using higher amounts or intravenous glutamine have not reported this effect.^{238 , 239}

Intravenous use of glutamine in people undergoing bone marrow transplants, a procedure sometimes used to allow very high amounts of chemotherapy to be used, has led to reduced hospital stays, leading to a savings of over $21,000 for each patient given glutamine.²⁴⁰

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.