Most people do not need to supplement histidine. Optimal levels for others remain unknown. Human research has used between 1 gram and 8 grams per day.
Dairy, meat and poultry, and fish are good sources of histidine.
According to limited research, many people with rheumatoid arthritis have low levels of histidine. Taking histidine supplements might improve arthritis symptoms in some people.1
No side effects have been reported with histidine. However, people with kidney or liver disease should not consume large amounts of amino acids without consulting a healthcare professional.
Last Review: 05-01-2013
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