Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
3 Stars Reliable and relatively consistent scientific data showing a substantial health benefit.
2 Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1 Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
Refer to label instructions
DMAE (2-dimethylaminoethanol) may increase levels of a brain neurotransmitter, which may foster positive behavior changes in people with dementia.
DMAE (2-dimethylaminoethanol) may increase levels of the brain neurotransmitter acetylcholine. In one preliminary trial, people with senile dementia were given DMAE supplements of 600 mg three times per day for four weeks. The participants did not show any changes in memory, though some did show positive behavior changes.1 However, a subsequent double-blind trial found no significant benefit from DMAE supplementation in people with Alzheimer’s disease.2
Refer to label instructions
Taking dimethylaminoethanol may help reduce symptoms.
Dimethylaminoethanol (DMAE) is a natural choline precursor. Although some preliminary data suggested that DMAE could decrease TD symptoms,3 most studies show that DMAE is no more effective than placebo for TD.4
DMAE supplementation is not recommended at this time.
DMAE is found as a supplement, although it is not widely available.
No deficiencies of DMAE are reported or believed to occur.
Clinical studies of DMAE have used up to 1,600 mg per day with no reports of side effects.5 For this reason, DMAE is believed to be relatively nontoxic. However, one study using higher intakes for Alzheimer’s disease patients did report symptoms of drowsiness and confusion with the use of DMAE.6 A possible side effect of lucid dreaming (in which the dreamer is conscious and in control of a dream) is suggested with DMAE use.7 Depression and hypomania (moderate symptoms of mania) have been reported as side effects of DMAE.8
1. Ferris SH, Sathananthan G, Gershon S, et al. Senile dementia. Treatment with Deanol. J Am Geriatr Soc 1977;25:241–4.
2. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer’s disease. Am J Psychiatry 1981;138:970–2.
3. Casey DE, Denney D. Dimethylaminoethanol in tardive dyskinesia. N Engl J Med 1974;291:797 [letter].
4. Soares, KV, McGrath JJ. The treatment of tardive dyskinesia–a systematic review and meta-analysis. Schizophr Res 1999;39:1–16 [review].
5. Casey DE, Denney D. Dimethylaminoethanol in tardive dyskinesia. N Engl J Med 1974;291:797.
6. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer’s disease. Am J Psychiatry 1981;138:970–2.
7. Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses 1988;26:255–7.
8. Casey DE. Mood alterations during deanol therapy. Psychopharmacology 1979;62:187–91.
Last Review: 05-01-2013
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2014.
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