Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
3 Stars Reliable and relatively consistent scientific data showing a substantial health benefit.
2 Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1 Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
Refer to label instructions
According to one report, about half of the people with porphyria cutanea tarda who took adenosine monophosphate saw complete alleviation of their photosensitivity.
Adenosine monophosphate (AMP) is a substance made in the body that is also distributed as a supplement, although it is not widely available. According to one report, 90% of people with porphyria cutanea tarda responded well to 160 to 200 mg of AMP per day taken for at least one month.1 Complete alleviation of photosensitivity occurred in about half of the people who took AMP.
Shingles and Postherpetic Neuralgia
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Adenosine monophosphate has been found to speed healing, reduce the duration of pain of shingles, and prevent the development of postherpetic neuralgia.
Adenosine monophosphate (AMP), a compound that occurs naturally in the body, has been found to be effective against shingles outbreaks. In one double-blind trial, people with an outbreak of shingles were given injections of either 100 mg of AMP or placebo three times a week for four weeks. Compared with the placebo, AMP promoted faster healing and reduced the duration of pain of the shingles.2 In addition, AMP appeared to prevent the development of postherpetic neuralgia.3 , 4
The body creates AMP within cells during normal metabolic processes. AMP is also found as a supplement, although it is not widely available.
Preliminary research suggests that people with herpes simplex or herpes zoster (shingles) infections may have low levels of AMP; however, the clinical significance of this finding is unclear.5
The limited number of human studies involving oral AMP have not indicated any side effects. However, some researchers have expressed concern that supplemental intake of AMP could, in theory, increase levels of adenosine, a substance related to AMP that may interfere with immune function.6 Doctors using AMP injections report that too-rapid intravenous administration or inadvertent administration of an intramuscular injection into a vein could cause life-threatening arrhythmias of the heart.7
1. Gajdos A. AMP in porphyria cutanea tarda. Lancet 1974;I:163 [letter].
2. Bernstein JE, Korman NJ, Bickers DR, et al. Topical capsaicin treatment of chronic postherpetic neuralgia. J Am Acad Dermatol 1989;21:265–70.
3. Sklar SH, Blue WT, Alexander EJ, et al. Herpes zoster. The treatment and prevention of neuralgia with adenosine monophosphate. JAMA 1985;253:1427–30.
4. Sklar SH, Wigand JS. Herpes zoster. Br J Dermatol 1981;104:351–2.
5. Sklar SH. Herpes virus infection. JAMA 1977;237:871–2.
6. Sherlock CH, Corey L. Adenosine monophosphate for the treatment of varicella zoster infections: A large dose of caution. JAMA 1985;253:1444–5.
7. Gaby AR, Wright JV. Nutritional Therapy in Medical Practice. Proceedings from Nutritional Therapy in Medical Practice Conference, Seattle, WA, Oct 25–8, 1996, 33; firstname.lastname@example.org.
Last Review: 05-01-2013
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2014.
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