Triazolam is used for the short-term treatment of insomnia, and is in a family of drugs known as benzodiazepines.
A preliminary study showed that taking melatonin and triazolam together produces better quality of sleep than occurs when the drug is taken alone. The results also indicated that less triazolam is needed when melatonin and triazolam are taken together, which might reduce side effects such as morning grogginess.1 Additional research is needed to determine whether individuals taking triazolam should also take melatonin.
In a preliminary trial, an extract of periwinkle called vinpocetine was shown to produce minor improvements in short-term memory among people taking flunitrazepam, a benzodiazepine.2 Further study is needed to determine if vinpocetine would be a helpful adjunct to use of benzodiazepines, or triazolam specifically.
Drinking grapefruit juice with triazolam dramatically increases the amount of drug absorbed and the amount of time it stays in the body.3 Though the clinical significance of this interaction is unknown, some people may experience increased side effects, such as morning grogginess, dizziness, and poor coordination. Therefore, people taking triazolam should probably avoid drinking grapefruit juice or eating grapefruit for the duration of therapy.
Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice.4 , 5 The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with triazolam in the same way that grapefruit juice does.
1. Ferini-Strambi L, Zucconi M, Biella G, et al. Effect of melatonin on sleep microstructure: preliminary results in healthy subjects. Sleep 1993;16:744–7..
2. Bhatti JZ, Hindmarch I. Vinpocetine effects on cognitive impairments produced by flunitrazepam. Int Clin Psychopharmacol 1987;2:325–31.
3. Sifton DW, ed. Physicians’ Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2461–3.
4. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705–6.
5. Summers KM. Potential drug-food interactions with pomegranate juice. Ann Pharmacother 2006;40:1472–3.
Last Review: 05-01-2013
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