Digitalis (Digitalis lanata, Digitalis purpurea) refers to a family of plants commonly called foxglove that contain digitalis glycosides, chemicals with actions and toxicities similar to the prescription drug digoxin.

Trazodone was associated with increased serum digoxin levels in one case report.¹ No interactions between trazodone and digitalis have been reported. Until more is known, trazodone and digitalis-containing products should be used only under the direct supervision of a doctor trained in their use.

There is one case report of an elderly patient with Alzheimer’s disease going into a coma while concurrently using trazodone and ginkgo.² Until more is known, ginkgo should not be combined with trazodone except under supervision of a doctor.

One report described a case of serotonin syndrome in a patient who took St. John’s wort and trazodone.³ The patient reportedly experienced mental confusion, muscle twitching, sweating, flushing, and ataxia. Until more is known, St. John’s wort should not be combined with trazodone except under expert clinical supervision.