Sildenafil is a drug used to treat erectile dysfunction (ED), commonly known as impotence, in men.
Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice.2 , 3 The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with sildenafil in the same way that grapefruit juice does.
1. Jetter A, Kinzig-Schippers M, Walchner-Bonjean M, et al. Effects of grapefruit juice on the pharmacokinetics of sildenafil. Clin Pharmacol Ther 2002;71:21–9.
2. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705–6.
3. Summers KM. Potential drug-food interactions with pomegranate juice. Ann Pharmacother 2006;40:1472–3.
Last Review: 05-01-2013
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