Isotretinoin is a modified vitamin A molecule used to treat severe acne vulgaris.
Preliminary research has found that combined administration of isotretinoin and vitamin E (alpha-tocopherol) substantially reduces the initial toxicity of high-dose isotretinoin without reducing drug efficacy.1 Additional research is needed to further clarify this potentially beneficial interaction.
Although little is known about how isotretinoin interacts with real vitamin A, the two are structurally similar and have similar toxicities. Therefore, people taking isotretinoin should avoid vitamin A supplements at levels higher than typically found in a multivitamin (10,000 IU per day).
Last Review: 11-07-2012
Copyright © 2012 Aisle7. All rights reserved. Aisle7.com
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. The Aisle7 knowledgebase does not contain every possible interaction.
The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2013.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.