Topic Contents

Mirtazapine

Drug Information

Mirtazapine is used to treat people with mental depression, especially those who are also nervous and have trouble sleeping. It is in a class of drugs called tetracyclic antidepressants.

Common brand names:

Remeron, Remeron SolTab

Summary of Interactions with Vitamins, Herbs, & Foods

What Are Nutrient Interactions

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

none

Reduce Side Effects

none

Support Medicine

none

Reduces Effectiveness

none

Potential Negative Interaction

none

Explanation Required

Melatonin

Taking mirtazapine results in enhanced secretion of melatonin at night;¹ this may explain part of the mechanism of the effects of mirtazapine. Controlled research is needed to determine whether melatonin supplementation might enhance either the beneficial or the adverse effects of mirtazapine.

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

References

1. Palazidou E, Papadopoulos A, Sitsen A, et al. An alpha 2 adenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man. Psychopharmacology (Berl) 1989;97:115–7.

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Last Review: 11-07-2012

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