Hyoscyamine is used in the treatment of peptic ulcers and of Parkinson’s disease to reduce stiffness, tremors, and excess sweating. It acts as a drying agent in the treatment of hay fever and is also used to treat spasm and increased movement of both the intestines in irritable bowel syndrome and the bladder in urinary tract infections. Hyoscyamine is a belladonna alkaloid in a class of drugs known as anticholinergic antispasmodics.
Absorption of ferrous citrate, an iron compound that is usually well absorbed, is reduced in individuals taking hyoscyamine;1 therefore, these two substances should not be taken at the same time.
The herb Anisodus tanguticus contains a chemical that has effects similar to atropine, a compound related to hyoscyamine.2 Though no human studies have investigated a possible adverse interaction between hyoscyamine and anisodus, individuals should avoid the combination until more is known.
1. Orrego-Matte H, Fernandez O, Mena I. Effect of anticholinergic agents on the intestinal absorption of 59 Fe ferrous citrate. Am J Dig Dis 1971;16:789–95.
2. Qicheng F. Some current study and research approaches relating to the use of plants in the traditional Chinese medicine. J Ethnopharmacol 1980;2:57–63.
Last Review: 02-05-2013
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