An individual who took hydroxychloroquine and vitamin B6 together for nine years experienced a complete disappearance of skin nodules caused by rheumatoid arthritis.1 Controlled study is needed to determine whether taking vitamin B6 with or without hydroxychloroquine might help eliminate nodules in people with rheumatoid arthritis.
Magnesium supplementation may reduce blood levels of chloroquine, a compound similar to hydroxychloroquine, and decrease its effectiveness.2 Until more is known, people taking hydroxychloroquine for arthritis who are also using magnesium supplements and are not experiencing relief might try avoiding the supplements or taking them at separate times.
Last Review: 05-01-2013
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