Topic Contents

Clofibrate

Drug Information

Clofibrate is a drug used to lower cholesterol in people with high blood cholesterol. It is rarely used, due to the possibility of liver damage and the availability of safer, more effective drugs.

Common brand names:

Atromid-S

Summary of Interactions with Vitamins, Herbs, & Foods

What Are Nutrient Interactions

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

Vitamin B12

Clofibrate has been reported to reduce absorption of vitamin B12.¹

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Reduce Side Effects

Milk Thistle

Although there have been no clinical studies, use of milk thistle (Silibum marianum) with clofibrate may theoretically lower the risk of liver side effects associated with the drug. People may take a standardized milk thistle extract supplying 70–80% silymarin at an amount of 200 mg three times per day.

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Support Medicine

none

Reduces Effectiveness

none

Potential Negative Interaction

none

Explanation Required

none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

References

1. Robinson C, Weigly E. Basic Nutrition and Diet Therapy. New York: Macmillan, 1984, 46–54.

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Last Review: 11-07-2012

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