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Chlorzoxazone

Drug Information

Chlorzoxazone is used to treat acute painful muscle conditions. It is a type of drug called a centrally acting skeletal muscle relaxant.

Common brand names:

Paraflex, Parafon Forte DSC, Remular-S

Summary of Interactions with Vitamins, Herbs, & Foods

What Are Nutrient Interactions
Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • none

Reduce Side Effects

  • none

Support Medicine

  • none

Reduces Effectiveness

  • Cruciferous Vegetables

    Test tube studies show that watercress, garlic, tea, and cruciferous vegetables, such as Brussels sprouts, broccoli, and Chinese cabbage, block the breakdown of chlorzoxazone into inactive compounds.1 , 2 Controlled human research is needed to determine whether these interactions are important in people taking chlorzoxazone.

  • Garlic

    Test tube studies show that watercress, garlic, tea, and cruciferous vegetables, such as Brussels sprouts, broccoli, and Chinese cabbage, block the breakdown of chlorzoxazone into inactive compounds.3 , 4 Controlled human research is needed to determine whether these interactions are important in people taking chlorzoxazone.

  • Tea

    Test tube studies show that watercress, garlic, tea, and cruciferous vegetables, such as Brussels sprouts, broccoli, and Chinese cabbage, block the breakdown of chlorzoxazone into inactive compounds.5 , 6 Controlled human research is needed to determine whether these interactions are important in people taking chlorzoxazone.

Potential Negative Interaction

  • Foods with Caffeine

    Controlled studies show that chlorzoxazone reduces the elimination of caffeine from the body,7 which could cause side effects of caffeine, such as restlessness and insomnia. If side effects occur, some individuals may need to avoid caffeinated beverages, such as coffee and tea, while taking chlorzoxazone.

Explanation Required 

  • none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

References

1. Walter-Sack I, Klotz U. Influence of diet and nutritional status on drug metabolism. Clin Pharmacokin 1996;31:47–64.

2. Marchand LL, Wilkinson GR, Wilkens LR. Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone. Cancer Epidemiol Biomarkers Prev 1999;8:495–500.

3. Walter-Sack I, Klotz U. Influence of diet and nutritional status on drug metabolism. Clin Pharmacokin 1996;31:47–64.

4. Marchand LL, Wilkinson GR, Wilkens LR. Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone. Cancer Epidemiol Biomarkers Prev 1999;8:495–500.

5. Walter-Sack I, Klotz U. Influence of diet and nutritional status on drug metabolism. Clin Pharmacokin 1996;31:47–64.

6. Marchand LL, Wilkinson GR, Wilkens LR. Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone. Cancer Epidemiol Biomarkers Prev 1999;8:495–500.

7. Berthou F, Goasduff T, Lucas D, et al. Interaction between two probes used for phenotyping cytochromes P4501A2 (caffeine) and P4502E1 (chlorzoxazone) in humans. Pharmacogenetics 1995;5:72–9.

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