Topic Contents

Azathioprine

Drug Information

Azathioprine is used to prevent organ rejection following kidney transplant and to treat severe cases of rheumatoid arthritis.

Common brand names:

Azasan, Imuran

Summary of Interactions with Vitamins, Herbs, & Foods

What Are Nutrient Interactions

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

Folic Acid

People receiving dialysis for kidney failure often have low blood levels of folic acid. However, folic acid blood levels should return to normal following kidney transplant. A preliminary study of people taking azathioprine to prevent organ rejection revealed that blood levels of folic acid remained well below those of individuals not taking the drug. The highest blood folic acid level was observed in an individual who had not taken azathioprine for two years.¹ Controlled studies are needed to determine whether people taking azathioprine should supplement with folic acid.

Reduce Side Effects

none

Support Medicine

none

Reduces Effectiveness

none

Potential Negative Interaction

none

Explanation Required

none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

References

1. Zazgornik J, Druml W, Balcke P, et al. Diminished serum folic acid levels in renal transplant recipients. Clin Nephrol 1982;18:306–10.

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Last Review: 11-07-2012

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