Reduce dietary copper absorption by supplementing with zinc; consult your doctor to determine the correct amount to use
Work with a nutritionist to make sure you avoid eating foods that are high in copper
Wilson’s disease is a genetic disorder that results in excessive accumulation of copper in many parts of the body, particularly the liver.
This condition is readily treatable, but if Wilson’s disease is left untreated, it can be fatal.
Wilson’s disease is initially silent and may first be noticed as fatigue, absent menstrual periods in premenopausal women, or repeated and unexplained spontaneous abortions. In more advanced stages, there may be headaches, tremors, uncoordinated limb movements, unsteady gait, drooling, difficulty swallowing, and joint pain. There also may also be strange thought patterns with unusual behaviors.
|Steer clear of copper||
Work with a nutritionist to make sure you avoid eating foods that are high in copper, such as oysters, nuts, dried legumes, cereals, potatoes, vegetables, and meat.
Most foods contain at least some copper, so it is not possible to avoid the metal completely. Foods high in copper, such as organ meats and oysters, should be eliminated from the diet. Some foods are relatively high in copper but are quite nutritious (for example, nuts and legumes)—these foods should be eaten in moderation by people with Wilson’s disease. Grains contain significant amounts of copper but are important components of a healthful diet, and dietary restriction may be neither wise nor necessary, particularly if zinc is supplemented.
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Supplementing with zinc may help reduce dietary copper absorption.
Zinc is known for its ability to reduce copper absorption and has been used successfully in patients with Wilson’s disease,1 with some trials lasting for years years.2 , 3 Researchers have called zinc a “remarkably effective and nontoxic therapy for Wilson’s disease.”4 The U.S. Food and Drug Administration has approved the use of zinc to treat Wilson’s disease for maintenance therapy following drug therapy, although some scientists recommend that it be considered for initial therapy as well.5
Zinc has also been used to keep normal copper levels from rising in people with Wilson’s disease who had previously been treated successfully with prescription drugs.6 Zinc (50 mg taken three times per day) has been used for such maintenance therapy,7 though some researchers have used the same amount of zinc to successfully treat people with Wilson’s disease who had not received drug therapy.8
Zinc is so effective in lessening the body’s burden of copper that a copper deficiency was reported in someone with Wilson’s disease who took too much (480 mg per day) zinc.9 Nonetheless, zinc may not help everyone with Wilson’s disease. Sometimes increased copper levels can occur in the liver after zinc supplementation;10 however, leading researchers believe this increase is temporary and may not be not harmful.11
Zinc supplementation (25 mg or 50 mg three times daily) has also been used to successfully treat pregnant women with Wilson’s disease.12 Management of Wilson’s disease with zinc should only be undertaken with the close supervision of a doctor.
1. Hoogenraad TU, Van den Hammer CJA, Van Hattum J. Effective treatment of Wilson’s disease with oral zinc sulphate: two case reports. Br Med J 1984;289:273–6.
2. Cossack ZT. The efficacy of oral zinc therapy as an alternative to penicillamine for Wilson’s disease. N Engl J Med 1988;318:322–3 [letter/review].
3. Brewer GJ, Dick RD, Johnson VD, et al. Treatment of Wilson’s disease with zinc: XV long-term follow-up studies. J Lab Clin Med 1998;132:264–78.
4. Brewer GJ, Yuzbasiyan-Gurkan V. The use of zinc-copper metabolic interactions in the treatment of Wilson’s disease. J Am Coll Nutr 1989;8:452 [abstract 103].
5. Hoogenraad TU. Zinc treatment of Wilson’s Disease. J Lab Clin Med 1998;132:240–1 [editorial].
6. Brewer GJ, Hill GM, Dick RD, et al. Treatment of Wilson’s disease with zinc. III. Prevention of reaccumulation of hepatic copper. J Lab Clin Med 1987;109:526–31.
7. Brewer GJ, Yuzbasiyan-Gurkan V. Use of zinc-copper metabolic interactions in the treatment of Wilson’s disease. J Am Coll Nutr 1990;9:487–91.
8. Brewer JG, Yuzbasiyan-Gurkan V, Lee D-Y, Appelman H. Treatment of Wilson’s disease with zinc. VI. Initial treatment studies. J Lab Clin Med 1989;114:633–8.
9. Van den Hamer CJA, Hoogenraad TU. Copper deficiency in Wilson’s disease. Lancet 1989;ii:442 [letter].
10. Van Caillie-Bertrand M, Degenhart HJ, Visser HKA, et al. Oral zinc sulphates for Wilson’s disease. Arch Dis Child 1985;60:656–9.
11. Brewer JG, Yuzbasiyan-Gurkan V, Lee D-Y, Appelman H. Treatment of Wilson’s disease with zinc. VI. Initial treatment studies. J Lab Clin Med 1989;114:633–8.
12. Brewer GJ, Johnson VD, Dick RD, et al. Treatment of Wilson’s disease with zinc. XVII: treatment during pregnancy. Hepatology 2000;31:364–70.
Last Review: 05-01-2013
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2014.
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