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Drug Information

Summary of Interactions with Vitamins, Herbs, & Foods

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • Zinc

    Though some studies indicate that supplementing with folic acid reduces blood levels of zinc, most show no interaction between the two nutrients when folic acid is taken at moderate levels.1 Therefore, until more convincing evidence is available, people taking moderate amounts of folic acid do not need to supplement with zinc. Zinc supplementation is recommended when folic acid intake is high. A doctor should be consulted to determine the appropriate time to add zinc supplementation to folic acid therapy.

Reduce Side Effects

  • none

Support Medicine

  • none

Reduces Effectiveness

  • Magnesium

    One controlled study showed that taking folic acid together with an antacid containing aluminum and magnesium hydroxide reduced the absorption of the vitamin.2 Therefore, individuals should take folic acid one hour before or two hours after taking antacids containing aluminum and magnesium hydroxide.

Potential Negative Interaction

  • none

Explanation Required 

  • Vitamin B6

    Folic acid and vitamin B6 have been used to reduce elevated blood levels of homocysteine, which has been associated with atherosclerosis. One controlled study showed that taking 0.3 mg of folic acid together with 120 mg of vitamin B6 reduced homocysteine levels more than taking either vitamin alone. The study also revealed that long-term supplementation with vitamin B6 alone might reduce blood folic acid levels.3 Therefore, people with elevated blood homocysteine levels should supplement with both folic acid and vitamin B6.

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

References

1. Campbell RC. How safe are folic acid supplements? Arch Intern Med 1996;156:1638–44 [review].

2. Russell RM, Golner BB, Krasinski SD, et al. Effect fo antacid and H2 receptor antagonists on the intestinal absorption of folic acid. J Lab Clin Med 1988;112:458–63.

3. Mansoor MA, Kristensen O, Hervig T, et al. Plasma total homocysteine response to oral doses of folic acid and pyridoxine hydrochloride (vitamin B6) in healthy individuals. Oral doses of vitamin B6 reduce concentrations of serum folate. Scand J Clin Lab Invest 1999;59:139–46.

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