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Etidronate

Drug Information

Common brand names:

Didronel

Summary of Interactions with Vitamins, Herbs, & Foods

What Are Nutrient Interactions

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

none

Reduce Side Effects

none

Support Medicine

none

Reduces Effectiveness

none

Potential Negative Interaction

none

Explanation Required

Calcium

Calcium supplements may interfere with alendronate absorption.¹ However, one researcher suggested that addition of large amounts of supplemental calcium to alendronate therapy in patients with bone metastases (with evidence of osteomalacia) related to prostate cancer might improve the clinical outcome.² Moreover, both calcium and alendronate are commonly used in the treatment of osteoporosis in the same people. To prevent potential interactions, alendronate should be taken two hours before or after calcium supplements.

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Magnesium

Absorption of tiludronate, a drug related to alendronate, is reduced when taken with magnesium and/or aluminum-containing antacids.³ This interaction has not yet been reported with alendronate. Until more is known, alendronate should be taken two hours before or after magnesium and/or aluminum-containing antacids.

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

References

1. Threlkeld DS, ed. Hormones, Bisphosphonates. InFacts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jul 1998, 134r.

2. Adami S. Bisphosphonates in prostate carcinoma. Cancer 1997;80:1674–9.

3. Threlkeld DS, ed. Hormones, Bisphosphonates. InFacts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jul 1998, 134r.

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Last Review: 11-07-2012

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2013.

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