Lupus and Antiphospholipid Antibody Syndrome

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Topic Overview

About 1 out of 3 people with lupus produce an antibody that attacks certain blood-clotting factors, which can cause the blood to clot easily.footnote 1 A person who has this antibody and has had blood clots is said to have antiphospholipid antibody syndrome. This can lead to mild or severe blood-clotting complications, including:

A blood test can detect antiphospholipid antibodies. When diagnosed, the condition is usually treated with anticoagulants. Pregnant women with antiphospholipid antibody syndrome need to be closely monitored.



  1. Crow MK (2012). Systemic lupus erythematosus. In L Goldman, A Schafer, eds., Goldman's Cecil Medicine, 24th ed., pp. 1697–1705. Philadelphia: Saunders.


ByHealthwise Staff
Primary Medical Reviewer Anne C. Poinier, MD - Internal Medicine
Specialist Medical Reviewer Nancy Ann Shadick, MD, MPH - Internal Medicine, Rheumatology

Current as ofSeptember 9, 2014