Neuroleptic Malignant Syndrome
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Neuroleptic Malignant Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Neuroleptic malignant syndrome is a rare but potentially life-threatening reaction to the use of almost any of a group of antipsychotic drugs or major tranquilizers (neuroleptics). These drugs are commonly prescribed for the treatment of schizophrenia and other neurological, mental, or emotional disorders. Several of the more commonly prescribed neuroleptics include thioridazine, haloperidol, chlorpromazine, fluphenazine and perphenazine.
The syndrome is characterized by high fever, stiffness of the muscles, altered mental status (paranoid behavior), and autonomic dysfunction. Autonomic dysfunction alludes to defective operations of the components of the involuntary (autonomic) nervous system, leading to wide swings of blood pressure, excessive sweating and excessive secretion of saliva.
A genetic basis for the disorder is suspected but not proven. It does appear to be clear that a defect in the receptors to dopamine (dopamine D2 receptor antagonism) is an important contributor to the cause of neuroleptic malignant syndrome.
Malignant Hyperthermia Association of the United States
1 North Main St
PO Box 1069
Sherburne, NY 13460
North American Malignant Hyperthermia Registry
Penn State University
Dept. of Anesthesiology
P.O. Box 850
Hershey, PA 17033-0850
National Mental Health Consumers' Self-Help Clearinghouse
1211 Chestnut Street
Philadelphia, PA 19107-6312
Mental Health America
2000 N. Beauregard Street, 6th Floor
Alexandria, VA 22314-2971
National Alliance on Mental Illness
3803 N. Fairfax Drive
Arlington, VA 22203-
NIH/National Institute of Mental Health
Health Science Writing, Press and Dissemination Branch
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Room 8184, MSC 9663
Bethesda, MD 20892-9663
MedicAlert Foundation International
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It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
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Last Updated: 5/1/2008
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