Sarcoidosis

National Organization for Rare Disorders, Inc.

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Important
It is possible that the main title of the report Sarcoidosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Sarcoid of Boeck
  • Schaumann's Disease

Disorder Subdivisions

  • None

General Discussion

Sarcoidosis is a multisystem disorder that most often affects individuals between 20 and 40 years of age. Females appear to be affected more frequently than males. Sarcoidosis is characterized by the abnormal formation of inflammatory masses or nodules (granulomas) consisting of certain granular white blood cells (modified macrophages or epithelioid cells) in certain organs of the body. The granulomas that are formed are thought to alter the normal structure of and, potentially, the normal functions of, the affected organ(s), causing symptoms associated with the particular body system(s) in question. In individuals with sarcoidosis, such granuloma formation most commonly affects the lungs. However, in many cases, the upper respiratory system, lymph nodes, skin, and/or eyes may be involved. In addition, in some cases, other organs may be affected, including the liver, bone marrow, spleen, musculoskeletal system, heart, salivary glands, and/or nervous system (i.e., central or peripheral nervous system).

The range and severity of symptoms associated with sarcoidosis vary greatly, depending upon the specific organ(s) involved and the degree of such involvement. In some cases, the symptoms of sarcoidosis may begin suddenly (acute), sometimes severely, and subside in a relatively short period of time (self limited). Acute sarcoidosis is often characterized by fatigue, fever, generalized muscle aches, difficulty breathing (dyspnea), joint pain, swollen glands, skin eruptions, eye irregularities, and/or other symptoms. In the subacute form, affected individuals may experience no symptoms (asymptomatic), even with organ involvement. In the chronic form of sarcoidosis, symptoms may appear slowly and subtly, and may persist or recur over a long time span. Initial symptoms of the chronic form of the disorder may include difficulty breathing (dyspnea), dry cough, limited airflow, and other respiratory abnormalities. Symptoms associated with other organ involvement may follow.

The exact cause of sarcoidosis is not known. However, possible infectious, environmental, genetic, and immunological factors are under investigation as potential causes of the disorder.

Supporting Organizations

American Autoimmune & Related Diseases

22100 Gratiot Ave.
Eastpointe, MI 48021
Tel: (586)776-3900
Fax: (586)776-3903
Tel: (800)598-4668
Email: aarda@aarda.org
Website: http://www.aarda.org/

American Lung Association

1301 Pennsylvania Ave NW
Suite 800
Washington, DC 20004
USA
Tel: (202)785-3355
Fax: (202)452-1805
Tel: (800)586-4872
Email: info@lungusa.org
Website: http://www.lungusa.org

AutoImmunity Community

Website: https://www.facebook.com/autoimmunityforum

Autoimmune Information Network, Inc.

PO Box 4121
Brick, NJ 8723
Fax: (732)543-7285
Email: autoimmunehelp@aol.com

Center for Peripheral Neuropathy

University of Chicago
5841 South Maryland Ave, MC 2030
Chicago, IL 60637
Tel: (773)702-5659
Fax: (773)702-5577
Website: http://peripheralneuropathycenter.uchicago.edu/

Erythema Nodosum Yahoo Support Group

Website: http://health.groups.yahoo.com/group/erythema_nodosum_Group/

European Society for Immunodeficiencies

1-3 rue de Chantepoulet
Geneva, CH 1211
Switzerland
Tel: 410229080484
Fax: 41229069140
Email: esid@kenes.com
Website: http://www.esid.org

Foundation for Sarcoidosis Research

1820 West Webster Avenue
Suite #304
Chicago, IL 60614
USA
Tel: (312)341-0500
Fax: (312)322-9808
Tel: (866)358-5477
Email: info@stopsarcoidosis.org
Website: http://www.stopsarcoidosis.org

Genetic and Rare Diseases (GARD) Information Center

PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
Website: http://rarediseases.info.nih.gov/GARD/

Janine Sarcoidosis Outreach Foundation

12600 Bissonnet
A4
Houston, TX 77099
Tel: (832)248-6621
Fax: (281)568-5775
Tel: (800)846-5158
Email: sarcoidosis@jsof.org
Website: http://www.jsof.org/

NIH/National Eye Institute

31 Center Dr
MSC 2510
Bethesda, MD 20892-2510
United States
Tel: (301)496-5248
Fax: (301)402-1065
Email: 2020@nei.nih.gov
Website: http://www.nei.nih.gov/

NIH/National Heart, Lung and Blood Institute

P.O. Box 30105
Bethesda, MD 20892-0105
Tel: (301)592-8573
Fax: (301)251-1223
Email: nhlbiinfo@rover.nhlbi.nih.gov
Website: http://www.nhlbi.nih.gov/

NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases

Information Clearinghouse
One AMS Circle
Bethesda, MD 20892-3675
USA
Tel: (301)495-4484
Fax: (301)718-6366
Tel: (877)226-4267
Email: NIAMSinfo@mail.nih.gov
Website: http://www.niams.nih.gov/

National Sarcoidosis Organization

RR#1
Sundre
Alberta, T0M 1X0
Canada
Tel: (403)556-9833
Email: nationalsarcoidosis@gmail.com
Website: http://www.nationalsarcoidosisorganization.com

National Sarcoidosis Resource Center

P.O. Box 1593
Piscataway, NJ 08855-1593
Tel: (732)699-0733
Fax: (732)699-0882
Email: sconroy846@aol.com
Website: http://www.nsrc-global.net

Ocular Immunology and Uveitis Foundation

5 Cambridge Center
8th Floor
Cambridge, MA 2142
Tel: (617)621-6377
Fax: (781)431-2042
Tel: (866)353-6377
Email: fosters@comcast.net
Website: http://www.uveitis.org

Sarcoid Networking Association

12619 S. Wilderness Way
Molalla, OR 97038
USA
Tel: 541-905-2092
Email: sarcoidinformation@sarcoidosisnetwork.org
Website: http://www.sarcoidosisnetwork.org

Sarcoidosis & Lyme Disease Support Australia

PO Box 629
Narellan, NSW 2567
Australia
Tel: 488603532
Email: support@sarcoidosisaustralia.com
Website: http://www.sarcoidosisaustralia.com

Sarcoidosis Center

6005 Park Ave
Suite 501
Memphis, TN 38119
USA
Tel: (901)761-5877
Fax: (901)761-2280
Email: sarcoid@sarcoidcenter.com
Website: http://www.sarcoidcenter.com

Sarcoidosis Online Sites (S.O.S.)

P.O. Box 150549
Cape Coral, FL 33915
Tel: (239)945-2414
Email: SarcoidosisOnlineSites@gmail.com
Website: http://www.sarcoidosisonlinesites.com

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  1/11/1970
Copyright  2004 National Organization for Rare Disorders, Inc.