estradiol oral

Pronunciation: ess tra DYE ole

Brand: Estrace

Estrace 2 mg

round, turquoise, imprinted with MJ 756

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Femtrace 0.9 mg

round, white, imprinted with WC 390, LOGO

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Estradiol 0.5 mg-BAR

oval, white, imprinted with b, 899 1/2

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Estradiol 1 mg-MYL

round, pink, imprinted with M, E 4

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Estradiol 1mg-BAR

oval, lavender, imprinted with b, 886 1

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Gynodiol 1 mg

round, pink, imprinted with 1259, Diamond

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Estradiol 0.5 mg-MYL

round, white, imprinted with M, E 3

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Estradiol 0.5 mg-WAT

round, white, imprinted with WATSON 528

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Estradiol 1 mg-APH

round, purple, imprinted with AP 026

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Estradiol 1 mg-WAT

round, gray, imprinted with WATSON 487

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Gynodiol 0.5 mg

round, lavender, imprinted with 0768, Diamond

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Gynodiol 1.5 mg

round, blue, imprinted with 0158, Diamond

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Estrace 0.5 mg

round, white, imprinted with 021, MJ

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Estrace 1 mg

round, purple, imprinted with MJ 755

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Estradiol 0.5 mg-APH

round, white, imprinted with AP 025

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Estradiol 2 mg-APH

round, turquoise, imprinted with AP 027

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Estradiol 2 mg-BAR

oval, green, imprinted with b, 887 2

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Estradiol 2 mg-MYL

round, blue, imprinted with M, E 5

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Estradiol 2 mg-WAT

round, green, imprinted with WATSON 488

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Femtrace 0.45 mg

round, white, imprinted with WC 389, LOGO

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What is the most important information I should know about estradiol?

Multum donot

You should not use estradiol if you have: liver disease, a bleeding disorder, unusual vaginal bleeding, history of a hormone-dependent cancer (such as breast, uterine, ovarian, or thyroid cancer), or if you have ever had a heart attack, stroke, or a blood clot.

Multum nopreg

Do not use if you are pregnant.

Multum calldoc

Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Call your doctor at once if you have any unusual vaginal bleeding while using this medicine.

Multum donot

Estradiol should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions. Long-term use may also increase your risk of breast cancer or blood clot.

Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

What is estradiol?

Estradiol is a form of estrogen, a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Estradiol is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Estradiol is sometimes used as part of cancer treatment in women and men.

Estradiol may also be used for other purposes not listed in this medication guide.

What should I discuss with my health care provider before taking estradiol?

Multum donot

You should not use this medicine if you are allergic to estradiol, if you are pregnant, or if you have:

  • unusual vaginal bleeding that a doctor has not checked;
  • liver disease;
  • a bleeding or blood-clotting disorder;
  • a recent history of heart attack or stroke;
  • a history of hormone-dependent cancer (such as breast, uterine, ovarian, or thyroid cancer);
  • if you have ever had a blood clot (especially in your lung or your lower body); or
  • if you are allergic to any medicines or food dyes.
Multum donot

Estradiol should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.

To make sure estradiol is safe for you, tell your doctor if you have:

  • heart disease;
  • risk factors for coronary artery disease (such as diabetes, lupus, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, or if you have had a hysterectomy);
  • a history of jaundice caused by pregnancy or birth control pills;
  • a thyroid disorder;
  • kidney disease;
  • asthma;
  • epilepsy or other seizure disorder;
  • migraines;
  • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
  • endometriosis or uterine fibroid tumors;
  • gallbladder disease;
  • high or low levels of calcium in your blood; or
  • if you have had your uterus removed (hysterectomy).
Multum emt

Long-term use of estradiol may increase your risk of breast cancer, heart attack, stroke, or blood clot. Talk with your doctor about your individual risks before using estradiol long term.

Multum nopreg

FDA pregnancy category X. Do not use estradiol if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medicine.

Multum nobrfeed

Estradiol can pass into breast milk. This medication may slow breast milk production. Tell your doctor if you are breast-feeding a baby.

How should I take estradiol?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Multum donot

Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to take while you are using estradiol, to help lower this risk. Report any unusual vaginal bleeding right away.

Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis while using estradiol.

If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using estradiol.

Multum rt

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause nausea, vomiting, or vaginal bleeding.

What should I avoid while using estradiol?

Grapefruit and grapefruit juice may interact with estradiol and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.

What are the possible side effects of estradiol?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum calldoc

Call your doctor at once if you have:

  • heart attack symptoms --chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • signs of a stroke --sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot in the lung --chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;
  • signs of a blood clot in your leg --pain, swelling, warmth, or redness in one or both legs;
  • swelling or tenderness in your stomach;
  • jaundice (yellowing of the skin or eyes);
  • unusual vaginal bleeding;
  • a lump in your breast;
  • fluid retention (swelling, rapid weight gain); or
  • high levels of calcium in your blood --numbness or tingly feeling around your mouth, fast or slow heart rate, muscle tightness or contraction, overactive reflexes.

Common side effects may include:

  • breast pain;
  • headache;
  • vaginal itching or discharge, changes in your menstrual periods, light vaginal bleeding or spotting;
  • thinning scalp hair; or
  • nausea, vomiting, bloating, stomach cramps.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect estradiol?

Other drugs may interact with estradiol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about estradiol.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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