Pronunciation: na PROX en

Brand: Aleve, Anaprox, EC-Naprosyn, Flanax Pain Reliever, Leader Naproxen Sodium, Midol Extended Relief, Naprelan 375, Naprosyn

EC-Naprosyn 500 mg

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oval, white, imprinted with EC-NAPROSYN, 500

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Naprelan 375 mg

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oblong, white, imprinted with W, 901

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Naprelan 375 mg-VIC

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oblong, white, imprinted with N, 375

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Naprelan 500 mg

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oblong, white, imprinted with W, 902

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Naprosyn 250 mg

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round, yellow, imprinted with NAPROSYN 250, ROCHE

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Naprosyn 500 mg

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oblong, yellow, imprinted with NAPROSYN, 500

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Naproxen 250 mg-AMN

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round, white, imprinted with IP188, 250

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Naproxen 250 mg-DAV

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round, pink, imprinted with MOVA, 250 M25

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Naproxen 250 mg-GG

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round, yellow, imprinted with GG 724

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Naproxen 250 mg-MYL

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round, white, imprinted with 377, MYLAN

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Naproxen 250 mg-PER

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round, white, imprinted with L121

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Naproxen 250 mg-TEV

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round, pink, imprinted with 93, 147

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Naproxen 250 mg-WAT

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round, white, imprinted with WATSON 821

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Naproxen 275 mg-APH

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elliptical, white, imprinted with INV286

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Naproxen 275 mg-GG

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elliptical, yellow, imprinted with GG 417

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Naproxen 275 mg-MYL

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round, blue, imprinted with M, 537

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Naproxen 275 mg-TEV

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oval, white, imprinted with 93, 536

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Naproxen 375 mg EC-ETH

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round, white, imprinted with 302, ETHEX

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Naproxen 375 mg EC-GG

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oblong, white, imprinted with GG 935

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Naproxen 375 mg-AMN

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capsule, white, imprinted with IP189, 375

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Naproxen 375 mg-DR-TEV

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oval, white, imprinted with 93-5

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Naproxen 375 mg-GG

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oblong, peach, imprinted with GG 725

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Naproxen 375 mg-MYL

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oblong, white, imprinted with 555, MYLAN

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Naproxen 375 mg-TEV

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oblong, peach, imprinted with 93, 148

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Naproxen 375 mg-WAT

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oblong, gray, imprinted with WATSON 822

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Naproxen 500 mg EC-ETH

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oblong, white, imprinted with ETHEX, 303

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Naproxen 500 mg EC-GG

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oblong, white, imprinted with GG 936

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Naproxen 500 mg-AMN

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capsule, white, imprinted with 500, IP190

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Naproxen 500 mg-DAV

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oblong, pink, imprinted with MOVA, 500 M50

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Naproxen 500 mg-DR-TEV

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oval, white, imprinted with 93-6

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Naproxen 500 mg-GG

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oblong, yellow, imprinted with GG 726

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Naproxen 500 mg-MYL

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oblong, white, imprinted with MYLAN, 451

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Naproxen 500 mg-TEV

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oblong, pink, imprinted with 93, 149, TEVA

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Naproxen 500 mg-WAT

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oval, white, imprinted with WATSON 791

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Naproxen 550 mg-APH

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oblong, white, imprinted with INV287

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Naproxen 550 mg-TEV

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oblong, white, imprinted with 93, 537

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Naproxen Sodium 275 mg-AMN

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oval, blue, imprinted with IP193

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Naproxen Sodium 275 mg-WAT

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oval, white, imprinted with WATSON 792

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Naproxen Sodium 550 mg-AMN

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oval, blue, imprinted with IP 194

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Naproxen Sodium 550 mg-WAT

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oval, green, imprinted with WATSON 793

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What is the most important information I should know about naproxen?

Naproxen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Naproxen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using naproxen, especially in older adults.

What is naproxen?

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Naproxen works by reducing hormones that cause inflammation and pain in the body.

Naproxen is used to treat pain or inflammation caused by conditions such as arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps.

The delayed-release or extended-release tablets are slower-acting forms of naproxen that are used only for treating chronic conditions such as arthritis or ankylosing spondylitis. These forms of naproxen will not work fast enough to treat acute pain.

Naproxen may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking naproxen?

Naproxen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.

Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Naproxen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using naproxen, especially in older adults.

You should not use naproxen if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have:

  • heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;
  • a history of heart attack, stroke, or blood clot;
  • a history of stomach ulcers or bleeding;
  • asthma;
  • liver or kidney disease; or
  • fluid retention.

Taking naproxen during the last 3 months of pregnancy may harm the unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.

Naproxen can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Naproxen is not approved for use by anyone younger than 2 years old. Do not give this medicine to a child without medical advice.

How should I take naproxen?

Use exactly as directed on the label, or as prescribed by your doctor. Do not take this medicine in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.

Do not crush, chew, or break a naproxen tablet. Swallow it whole.

Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

If you change brands, strengths, or forms of naproxen, your dosage needs may change. Ask your pharmacist if you have any questions about the kind of naproxen you are using.

If a child is using this medicine, tell your doctor if the child has any changes in weight. Naproxen doses are based on weight in children, and any changes may affect your child's dose.

If you use naproxen long-term, you may need frequent medical tests.

This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using naproxen.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

What happens if I miss a dose?

Since naproxen is sometimes used only when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking naproxen?

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Avoid taking aspirin while you are taking naproxen.

Ask a doctor or pharmacist before using any cold, allergy, or pain medicine. Many medicines available over the counter contain aspirin or other medicines similar to naproxen. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen.

Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb naproxen.

What are the possible side effects of naproxen?

Get emergency medical help if you have signs of an allergic reaction: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Stop using naproxen and call your doctor at once if you have:

  • shortness of breath (even with mild exertion);
  • swelling or rapid weight gain;
  • the first sign of any skin rash, no matter how mild;
  • signs of stomach bleeding --bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • liver problems --nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • kidney problems --little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;
  • low red blood cells (anemia) --pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
  • severe skin reaction --fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • indigestion, heartburn, stomach pain, nausea;
  • diarrhea, constipation;
  • headache, dizziness, drowsiness;
  • swelling in your hands or feet;
  • bruising, itching, rash, sweating; or
  • ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect naproxen?

Ask your doctor before using naproxen if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Ask a doctor or pharmacist if it is safe for you to use naproxen if you are also using any of the following drugs:

  • lithium;
  • methotrexate;
  • probenecid;
  • a blood thinner (warfarin, Coumadin, Jantoven);
  • heart or blood pressure medication, including a diuretic or "water pill"; or
  • steroid medicine (such as prednisone).

This list is not complete. Other drugs may interact with naproxen, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about naproxen.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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