Advair DiskusSkip to the navigation
This drug combines two primary active ingredients: salmeterol and fluticasone.
Salmeterol is a member of the drug family known as long-acting, beta-adrenergic bronchodilators (also called beta-agonists). It is inhaled by mouth, into the lungs, to treat asthma and prevent bronchospasm. Salmeterol is also used to prevent exercise-induced bronchospasm.
Fluticasone is a type of corticosteroid that is inhaled by mouth to treat and prevent asthma, as well as other inflammatory conditions of the lungs that restrict breathing. Oral corticosteroids are inhaled into the nose to treat and prevent symptoms of hay fever and other allergies, and some may be used to prevent recurrence of nasal polyps after surgical removal.
Some of the information in this article pertains to inhaled corticosteroids in general, not fluticasone specifically. The interactions reported here may not apply to all the Also Indexed As terms. Talk to your doctor or pharmacist if you are taking any of these drugs.
Common brand names:Advair Diskus, Advair HFA
Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
Most of an inhaled dose of beclomethasone is actually swallowed, which may lead to reduced absorption of calcium.1 Health practitioners may recommend calcium supplementation to individuals using beclomethasone inhalers.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
A group of women with asthma who had been taking inhaled beclomethasone were shown to have low levels of DHEA compared to women with asthma who were not taking beclomethasone.2 The authors speculated that this effect may partially explain how corticosteroids can cause osteoporosis. However, more research is needed to confirm these suspicions and to evaluate whether supplemental DHEA is beneficial to patients taking inhaled corticosteroids.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Reduce Side Effects
In animal research, applying aloe (Aloe vera) gel topically along with a topical corticosteroid enhanced the hormone’s anti-inflammatory activity in the skin.3 No human research has investigated this effect.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
A test tube study demonstrated that the bronchodilating effects of salbutamol, another beta-adrenergic bronchodilator drug, were significantly increased by the addition of forskolin, the active component of the herb Coleus forskohlii.4 The results of this preliminary research suggest that the combination of forskolin and beta-agonists might provide an alternative to raising the doses of the beta-agonist drugs as they lose effectiveness. Until more is known, coleus should not be combined with salmeterol without the supervision of a doctor.
Zinc and Biotin
Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.5 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.
Potential Negative Interaction
1. Smith BJ, Phillips PJ, Pannall PR. Effect of orally administered beclomethasone dipropionate on calcium absorption from the gut in normal subjects. Thorax 1993;48:890-3.
2. Smith BJ, Buxton JR, Dickeson J, Heller RF. Does beclomethasone dipropionate suppress dehydroepiandrosterone sulphate in postmenopausal women? Austral NZ J Med 1994;24:396-401.
3. Davis RH, Parker WL, Murdoch DP. Aloe vera as a biologically active vehicle for hydrocortisone acetate. J Am Podiatric Med Assoc 1991;81:1-9.
4. Yousif MH, Thulesius O. Forskolin reverses tachyphylaxis to the bronchodilator effects of salbutamol: an in-vitro study on isolated guinea-pig trachea. J Pharm Pharmacol 1999;51:181-6.
5. Camacho FM, Garcia-Hernandez MJ. Zinc aspartate, biotin, and clobetasol propionate in the treatment of alopecia areata in childhood. Pediatr Dermatol 1999;16:336-8 [letter].
Last Review: 04-29-2014
Copyright © 2014 Aisle7. All rights reserved. Aisle7.com
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. The Aisle7 knowledgebase does not contain every possible interaction.
The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.