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Royal jelly is a thick, milky substance produced by worker bees to feed the queen bee. The worker bees mix honey and bee pollen with enzymes in the glands of their throats to produce royal jelly.
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3 Stars Reliable and relatively consistent scientific data showing a substantial health benefit.
2 Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1 Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
This supplement has been used in connection with the following health conditions:
50 to 100 mg daily
Supplementing with royal jelly may lower cholesterol levels.
Royal jelly has prevented the cholesterol-elevating effect of nicotine1 and has lowered serum cholesterol in animal studies.2 Preliminary human trials have also found that royal jelly may lower cholesterol levels.3 , 4 An analysis of cholesterol-lowering trials shows that 50 to 100 mg per day is the typical amount used in such research.5
How It Works
How to Use It
Royal jelly in the amount of 50–100 mg per day has been used in most of the studies on cholesterol lowering.
Where to Find It
Royal jelly is available in liquid form (usually in glass vials), tablets, and capsules.
Because royal jelly is not an essential nutrient, deficiencies do not occur.
Interactions with Supplements, Foods, & Other Compounds
Interactions with Medicines
Allergic reactions are the most common side effect. Allergic reactions from oral intake of royal jelly can range from very mild (e.g., mild gastrointestinal upset) to more severe reactions, including asthma, anaphylaxis (shock), intestinal bleeding, and even death in people who are extremely allergic to bee products.6 , 7 , 8 People who are allergic to bee pollen, honey, or conifer and poplar trees should not use royal jelly orally. Topical use of royal jelly has been reported to cause skin irritations in some people.9
1. Abou-Hozaifa BM, Badr El-Din NK. Royal jelly, a possible agent to reduce the nicotine-induced atherogenic lipoprotein profile. Saudi Med J 1995;16:337-42.
2. Abou-Hozaifa BM, Roston AAH, El-Nokaly FA. Effects of royal jelly and honey on serum lipids and lipoprotein cholesterol in rats fed cholesterol-enriched diet. J Biomed Sci Ther 1993;9:35-44.
3. Cho YT. Studies on royal jelly and abnormal cholesterol and triglycerides. Am Bee J 1977;117:36-9.
4. Liusov VA, Zimin IU. Experimental rational and trial of therapeutic use of bee raising product in cardiovascular diseases. Kardiologia 1983;23:105-9 [in Russian].
5. Vittek J. Effect of royal jelly on serum lipids in experimental animals and humans with atherosclerosis. Experientia 1995;51:927-35.
6. Thien FCK, Leung R, Baldo BA, et al. Asthma and anaphylaxis induced by royal jelly. Clin Exp Allergy 1996;26:216-22.
7. Leung R, Ho A, Chan J, et al. Royal jelly consumption and hypersensitivity in the community. Clin Exp Allergy 1997;27:333-6.
8. Yonei Y, Shibagaki K, Tsukada N, et al. Case report: haemorrhagic colitis associated with royal jelly intake. J Gastroenterol Hepatol 1997;12:495-9.
9. Takahashi M, Matsuo I, Ohkido M. Contact dermatitis due to honeybee royal jelly. Contact Dermatitis 1983;9:452-5.
Last Review: 01-20-2015
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2016.