Ornithine Alpha-KetoglutarateSkip to the navigation
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3 Stars Reliable and relatively consistent scientific data showing a substantial health benefit.
2 Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1 Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
This supplement has been used in connection with the following health conditions:
10 to 30 grams daily
Supplementing with OKG has been shown to significantly improve wound healing and decrease the length of hospital stays.
Preliminary1 and controlled2 studies of people with severe burns and other types of injuries3 showed that supplementation with 10–30 grams of ornithine alpha-ketoglutarate (OKG) per day significantly improved wound healing and decreased the length of hospital stays. Improved healing from major trauma and surgery has also been demonstrated with oral supplements including several grams per day of glutamine.4
Refer to label instructions
Ornithine alpha-ketoglutarate (OKG) is believed to facilitate muscle growth by enhancing the body’s release of anabolic hormones, but this is based on effects seen in hospitalized and elderly people, not published research.
Ornithine alpha-ketoglutarate (OKG) is formed from the amino acids ornithine and glutamine and is believed to facilitate muscle growth by enhancing the body’s release of anabolic hormones. While this effect has been found in studies on hospitalized patients and elderly people,5 , 6 no studies on muscle growth in athletes using OKG have been published.
How It Works
How to Use It
Optimal levels remain unknown, though 10 grams per day has been used in clinical trials.
Where to Find It
Although the amino acids that comprise OKG are present in protein foods such as meat and poultry and fish, the OKG compound is found only in supplements.
A deficiency of OKG has not been reported.
Interactions with Supplements, Foods, & Other Compounds
Interactions with Medicines
1. Cynober L. Amino acid metabolism in thermal burns. JPEN 1989;13:196.
2. De Bandt JP, Coudray-Lucas C, Lioret N, et al. A randomized controlled trial of the influence of the mode of enteral ornithine alpha-ketoglutarate administration in burn patients. J Nutr 1998;128:563-9.
3. Cynober L. Ornithine alpha-ketoglutarate in nutritional support. Nutrition 1991;7:313-22 [review].
4. Romito RA. Early administration of enteral nutrients in critically ill patients. AACN Clin Issues 1995;6:242-56.
5. Le Boucher J, Cynober LA. Ornithine alpha-ketoglutarate: the puzzle. Nutrition 1998;14:870-3 [review].
6. Brocker P, Vellas B, Albarede J, et al. A two-centre, randomized, double blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects. Age Aging 1994;23:303-6.
Last Review: 07-08-2014
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.