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Inosine is a nucleoside, one of the basic compounds comprising cells. It is a precursor to adenosine, an important energy molecule, and plays many supportive roles in the body.
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3 Stars Reliable and relatively consistent scientific data showing a substantial health benefit.
2 Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1 Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
This supplement has been used in connection with the following health conditions:
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Inosine is a precursor to uric acid, which is believed to block the effect of a compound that may play a role in MS development. Patients given inosine in order to raise uric acid levels experienced improved function in one study.
Inosine is a precursor to uric acid, a compound that occurs naturally in the body. Uric acid is believed to block the effect of a toxic free-radical compound (peroxynitrite) that may play a role in the development of multiple sclerosis.1 In an attempt to raise uric acid levels, ten patients with MS were treated with inosine in amounts up to 3 grams per day for 46 weeks. Three of the ten treated patients showed some evidence of improved function and the others remained stable.2 Controlled studies are needed to confirm these preliminary results.
How It Works
How to Use It
Although a common amount of inosine taken by athletes is 5,000–6,000 mg per day, little scientific evidence supports the use of this supplement in any amount.
Where to Find It
Inosine is found in brewer’s yeast and organ meats. It is also available as a supplement.
Inosine is not an essential nutrient, so deficiencies do not occur.
Interactions with Supplements, Foods, & Other Compounds
Interactions with Medicines
No side effects have been reported with the use of inosine for two to five days in the limited research available. However, unused inosine is converted by the body to uric acid, which may be hazardous to people at risk for gout.
1. Koprowski H, Spitsin SV, Hooper DC. Prospects for the treatment of multiple sclerosis by raising serum levels of uric acid, a scavenger of peroxynitrite. Ann Neurol 2001;49:139.
2. Koprowski H, Spitsin SV, Hooper DC. Prospects for the treatment of multiple sclerosis by raising serum levels of uric acid, a scavenger of peroxynitrite. Ann Neurol 2001;49:139.
Last Review: 07-08-2014
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.