Gamma OryzanolSkip to the navigation
Gamma oryzanol is a naturally occurring mixture of plant chemicals called sterols and ferulic acid esters.
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3 Stars Reliable and relatively consistent scientific data showing a substantial health benefit.
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1 Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
This supplement has been used in connection with the following health conditions:
300 mg daily
Supplementing with gamma oryzanol may improve improve gastritis symptoms.
The results of several clinical trials suggest that gamma oryzanol supplementation can help people with gastritis and other gastrointestinal complaints. In one study, people with chronic gastritis were given 300 mg of gamma oryzanol per day.1 After two weeks, 23% of people taking gamma oryzanol reported that it was “extremely effective” and 55% rated it as “moderately effective.” Another study produced similar results: People with various types of gastritis received 300 mg of gamma oryzanol per day. After two weeks, more than 62% of those with superficial gastritis, more than 87% of those with atrophic gastritis, and all people with erosive gastritis experienced improvement. These results were confirmed in a large study involving approximately 2,000 people with various gastrointestinal complaints, including several forms of gastritis.2 Some of these people required as much as 600 mg per day for symptoms to improve. People with gastritis wishing to take gamma oryzanol for more than six months, or in amounts exceeding 300 mg per day, should first consult with a physician.
Refer to label instructions
Gamma oryzanol is a mixture of sterols and ferulic acid esters. One trial using ferulic acid in trained weight lifters found significantly more weight gain and increased strength compared with placebo.
Gamma oryzanol is a mixture of sterols and ferulic acid esters. Despite claims that gamma oryzanol or its components increase testosterone levels, stimulate the release of endorphins, and promote the growth of lean muscle tissue, research has provided little support for these claims and has also shown gamma-oryzanol to be poorly absorbed.3 A recent nine-week, double-blind trial of 500 mg per day of gamma-oryzanol in weight lifters found no benefit compared with placebo in strength performance gains or circulating anabolic hormones.4 However, a small, double-blind trial using 30 mg per day of ferulic acid for eight weeks in trained weight lifters did find significantly more weight gain (though lean body mass was not measured) and increased strength in one of three measures compared with placebo.5
How It Works
How to Use It
Much of the human research with gamma oryzanol used 300 mg per day. Healthy people do not appear to need this supplement.
Where to Find It
Gamma oryzanol is a natural component of rice bran, corn, and barley oils. Gamma oryzanol is also available as a supplement.
Since gamma oryzanol is not an essential nutrient, it is not associated with a deficiency state.
Interactions with Supplements, Foods, & Other Compounds
Interactions with Medicines
Some research suggests that gamma oryzanol taken in moderately high amounts (up to 600 mg per day) for several months can cause dry mouth, sleepiness, hot flushes, irritability, and light headedness in some individuals.6
1. Maruyama K, Kashiwazaki K, Toyama K, Tsuchiya M. Usefulness of Hi-Z fine granule (gamma-Oryzanol) for the treatment of autonomic instability in gastrointestinal system. Shinyaku To Rinsho 1976;25:124 [in Japanese].
2. Takemoto T, Miyoshi H, Nagashima H. Clinical trial of Hi-Z fine granules (gamma-oryzanol) on gastrointestinal symptoms at 375 hospitals (Japan). Shinyaku To Rinsho 1977;26 [in Japanese].
3. Wheeler KB, Garleb KA. Gamma oryzanol-plant sterol supplementation: metabolic, endocrine, and physiologic effects. Int J Sport Nutr 1991;1:170-7 [review].
4. Fry AC, Bonner E, Lewis DL, et al. The effects of gamma-oryzanol supplementation during resistance exercise training. Int J Sport Nutr 1997;7:318-29.
5. Bucci LR, Blackman G, Defoyd W, et al. Effect of ferulate on strength and body composition of weightlifters. J Appl Sport Sci Res 1990;4:110 [abstract].
6. Takemoto T, Miyoshi H, Nagashima H. Clinical trial of Hi-Z fine granules (gamma-oryzanol) on gastrointestinal symptoms at 375 hospitals (Japan). Shinyaku To Rinsho 1977;26 [in Japanese].
Last Review: 09-16-2014
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.