Drug Information

Raloxifene is a type of drug called a selective estrogen receptor modulator (SERM). It is used to prevent osteoporosis in women after menopause.

Common brand names:


Summary of Interactions with Vitamins, Herbs, & Foods

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • none

Reduce Side Effects

  • none

Support Medicine

  • none

Reduces Effectiveness

  • none

Potential Negative Interaction

  • none

Explanation Required 

  • Phytoestrogens
    Some chemicals called phytoestrogens, found naturally in plants, have estrogen-like activity; and some people use these phytoestrogens from dietary sources or from supplements to prevent or treat hormone-related health problems. In test tube studies, the estrogenic activity of one phytoestrogen, formononetin, was blocked by raloxifene.1 Further research is necessary to determine the overall effect of raloxifene on formononetin and other phytoestrogens in humans.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.


1. Ruh MF, Taylor JA, Howlett AC, Welshons WV. Failure of cannabinoid compounds to stimulate estrogen receptors. Biochem Pharmacol 1997;53:35-41.