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Losartan is used alone or in combination with hydrochlorothiazide (Hyzaar®) in the treatment of high blood pressure. It is a type of drug called an angiotensin II receptor antagonist.
Common brand names:Cozaar
Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
Losartan has been reported to increase urinary excretion of zinc, but the clinical significance of that finding is not certain.1The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Reduce Side Effects
Ingestion of grapefruit or grapefruit juice may increase the absorption of losartan by inhibiting an enzyme that breaks down the drug in the intestinal tract 2. Consumption of grapefruit products could therefore increase both the effectiveness and the adverse effects of this drug. People taking losartan should not use grapefruit products without medical supervision.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Potential Negative Interaction
Losartan has caused significant increases in blood potassium levels. Potassium supplements, potassium-containing salt substitutes (No Salt, Morton Salt Substitute, and others), and even high-potassium foods (including Noni juice) should be avoided by those taking losartan, unless directed otherwise by their doctor.3
1. Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy.Int J Clin Pract 2013;67:717–25.
2. Fuhr U. Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance. Drug Saf 1998;18:251-72.
3. Noni. Natural Medicines Comprehensive Database Web site. Accessed at www.naturaldatabase.com on September 13, 2011
Last Review: 04-29-2014
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