Isotretinoin is a modified vitamin A molecule used to treat severe acne vulgaris.
Preliminary research has found that combined administration of isotretinoin and vitamin E (alpha-tocopherol) substantially reduces the initial toxicity of high-dose isotretinoin without reducing drug efficacy.1 Additional research is needed to further clarify this potentially beneficial interaction.
Although little is known about how isotretinoin interacts with real vitamin A, the two are structurally similar and have similar toxicities. Therefore, people taking isotretinoin should avoid vitamin A supplements at levels higher than typically found in a multivitamin (10,000 IU per day).
Last Review: 04-29-2014
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