Drug Information

Econazole is an antifungal cream used for topical (direct application to the skin) treatment of fungal skin infections. It is used most commonly to treat athlete’s foot (fungal infection of the skin between the toes), jock itch (fungal infection of the skin in the groin region), and ringworm (fungal infection of nonhairy skin), and for external Candida infections. Econazole is for external use only.

Common brand names:


Summary of Interactions with Vitamins, Herbs, & Foods

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • none

Reduce Side Effects

  • none

Support Medicine

  • Echinacea

    The combination of oral echinacea (Echinacea purpurea, Echinacea angustifolia) with a topical econazole nitrate cream reduced the recurrence of vaginal yeast infections in women compared to those using the cream alone.1

    The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Reduces Effectiveness

  • none

Potential Negative Interaction

  • none

Explanation Required 

  • none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.


1. Coeugniet EG, Kuhnast R. Recurrent candidiasis: Adjuvant immunotherapy with different formulations of Echinacin. Therapiewoche 1986;36:3352-8.