Nadolol is used to treat both angina pectoris (chest pain) and high blood pressure, and it is in a class of drugs known as beta-adrenergic blockers. Since nadolol is related to propranolol, it may have similar interactions with dietary supplements and herbs.
Calcium supplements, if taken at the same time as some beta-blocker drugs, may reduce blood levels of the drug.2 However, whether calcium affects nadolol in this manner is unknown. Until more information is available, people on nadolol should take calcium supplements an hour before or two hours after the drug.
The active compound in willow (Salix alba), salicin, is converted to salicylic acid in the body. Taking salicylates with other beta-adrenergic blocking drugs has resulted in decreased absorption of the drugs.3 Therefore, until more is known about the interaction between willow and nadolol, they should not be taken at the same time.
As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides, it is best to avoid use of pleurisy root with heart medications such as beta-blockers.4
People taking nadolol may experience significant increases in blood levels of potassium,5 though it is unknown whether supplementation with potassium might enhance this effect. People taking beta-blockers should therefore avoid taking potassium supplements, or eating large quantities of high-potassium foods, such as fruit (e.g., bananas), unless directed to do so by their doctor.
1. Misaka S, Yatabe J, Muller F, et al. Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects.Clin Pharmacol Ther2014;95:432–8.
2. Burnham TH, ed. Cardiovascular Agents, Antiadrenergics/Sympatholytics, Beta-Adrenergic Blocking Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, 2000, 467-79.
3. Burnham TH, ed. Cardiovascular Agents, Antiadrenergics/Sympatholytics, Beta-Adrenergic Blocking Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, 2000, 467-79.
4. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213-4.
5. Wheeldon NM, McDevitt DG, Lipworth BJ. The effects of lower than conventional doses of oral nadolol on relative beta 1/beta 2-adrenoceptor blockade. Br J Clin Pharmacol 1994;38:103-8.
Last Review: 04-29-2014
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