Drug Information

Chlorhexidine is a mouthwash used to prevent and treat the redness, swelling, and bleeding gums associated with gingivitis. It is classified as an antimicrobial drug. No interactions are listed as it is not used internally.

Common brand names:

Peridex, PerioGard

Summary of Interactions with Vitamins, Herbs, & Foods

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • none

Reduce Side Effects

  • none

Support Medicine

  • none

Reduces Effectiveness

  • none

Potential Negative Interaction

  • Coffee

    Controlled studies show that drinking coffee and tea enhances the tooth-staining effect of chlorhexidine.1 People using chlorhexidine may prevent tooth staining if they consume coffee or tea an hour before or after using the drug, or if they avoid these beverages altogether.

  • Tea

    Controlled studies show that drinking coffee and tea enhances the tooth-staining effect of chlorhexidine.2 People using chlorhexidine may prevent tooth staining if they consume coffee or tea an hour before or after using the drug, or if they avoid these beverages altogether.

Explanation Required 

  • none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

References

1. Leard A, Addy M. The propensity of different brands of tea and coffee to cause staining associated with chlorhexidine. J Clin Periodontol 1997;24:115-8.

2. Leard A, Addy M. The propensity of different brands of tea and coffee to cause staining associated with chlorhexidine. J Clin Periodontol 1997;24:115-8.