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Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
Folic acid is needed by the body to utilize vitamin B12. Antacids, including sodium bicarbonate, inhibit folic acid absorption.1 People taking antacids are advised to supplement with folic acid.
Prolonged and frequent use of stimulant laxatives, including bisacodyl, may cause excessive and unwanted loss of water, potassium, and other nutrients from the body.2 , 3 Bisacodyl should be used for a maximum of one week, or as directed on the package label. Excessive use of any laxative can cause depletion of many nutrients. In order to protect against multiple nutrient deficiencies, it is important to not overuse laxatives.4 People with constipation should consult with their doctor or pharmacist before using bisacodyl.
In a study of nine healthy people, sodium bicarbonate administered with 10 mg of iron led to lower iron levels compared to iron administered alone.5 This interaction may be avoided by taking sodium bicarbonate-containing products two hours before or after iron-containing supplements.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
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Potential Negative Interaction
1. Russell RM, Golner BB, Krasinski SD, et al. Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid. J Lab Clin Med 1988;112:458-63.
2. Fleming BJ, Genuth SM, Gould AB, Kaminokowski MD. Laxative induced hypokalemia, sodium depletion, and hyperreninemia. Effects of potassium and sodium replacement on the rennin angiotensin system. Ann Intern Med 1975;83:60-2.
3. Threlkeld DS, ed. Gastrointestinal Drugs, Laxatives. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1991, 319a.
4. Threlkeld DS, ed. Gastrointestinal Drugs, Laxatives. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1991, 319a.
5. O'Neil-Cutting MA, Crosby WH. The effect of antacids on the absorption of simultaneously ingested iron. JAMA 1986;255:1468-70.
Last Review: 04-29-2014
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