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Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
Folic acid is needed by the body to utilize vitamin B12. Antacids, including sodium bicarbonate, inhibit folic acid absorption.1 People taking antacids are advised to supplement with folic acid.
In a study of nine healthy people, sodium bicarbonate administered with 10 mg of iron led to lower iron levels compared to iron administered alone.3 This interaction may be avoided by taking sodium bicarbonate-containing products two hours before or after iron-containing supplements.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Reduce Side Effects
Potential Negative Interaction
1. Russell RM, Golner BB, Krasinski SD, et al. Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid. J Lab Clin Med 1988;112:458-63.
2. Russell RM, Golner BB, Krasinski SD, et al. Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid. J Lab Clin Med 1988;112:458-63.
3. O'Neil-Cutting MA, Crosby WH. The effect of antacids on the absorption of simultaneously ingested iron. JAMA 1986;255:1468-70.
4. O'Neil-Cutting MA, Crosby WH. The effect of antacids on the absorption of simultaneously ingested iron. JAMA 1986;255:1468-70.
Last Review: 04-29-2014
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