Serum Protein Electrophoresis (SPE)

Why It Is Done

Serum protein electrophoresis is most often done to:

• Screen for a disease such as multiple myeloma, macroglobulinemia, or amyloidosis.
• Find the cause of hypogammaglobulinemia (HGG), a condition characterized by low levels of gamma globulin antibodies. HGG can make a person more susceptible to infection.

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Author:	Sydney Youngerman-Cole, RN, BSN, RNC	Last Updated: June 16, 2006
Medical Review:	Kathleen Romito, MD - Family Medicine Stanford M. Shoor, MD - Rheumatology
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