Alkaline Phosphatase

What To Think About

• If the alkaline phosphatase level is high, many health professionals will order a special test to help find the cause. This test is called alkaline phosphatase isoenzymes, or ALP isoenzymes.
• If liver disease is suspected, more blood tests, an ultrasound, or a CT scan are generally recommended to find the problem.
• Other tests to check liver function, such as alanine aminotransferase, aspartate aminotransferase, and bilirubin, are often done at the same time as an alkaline phosphatase (ALP) test. For more information, see the medical tests Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), and Bilirubin.
• Gamma glutamyl transferase (GGT), or gamma glutamyl transpeptidase, may be measured in the blood to check the difference between bone ALP and liver ALP. High levels of GGT are present when the liver is damaged but not present with bone disease. A high level of GGT may be caused by alcohol use or may mean that blocked bile ducts are causing inflammation. The level of GGT may be high with the use of certain medicines, such as phenytoin and phenobarbital. In some medical centers, a test that measures a substance called 5-nucleotidase is done instead of the GGT test because it is better at finding liver disease.

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Author:	Jan Nissl, RN, BS	Last Updated: August 21, 2006
Medical Review:	Caroline S. Rhoads, MD - Internal Medicine Alan C. Dalkin, MD - Endocrinology
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