Desmopressin acetate for von Willebrand's disease

Examples

Generic Name	Brand Name
desmopressin acetate (DDAVP)	Stimate

How It Works

Desmopressin increases the amount of clotting factor VIII, which helps blood to clot. It is available in a nasal spray form that is often prescribed. Desmopressin can also be injected.

Why It Is Used

Desmopressin is used for people with mild to moderate von Willebrand's disease. It is usually taken before dental and minor surgical procedures to help prevent severe bleeding. Desmopressin can also help control mild bleeding episodes. Some women may use desmopressin to lighten heavy menstrual periods. And some people use it before taking part in sports.

Desmopressin may not be used for:

• A person with type 2 or type 3 von Willebrand's disease.
• A child younger than 2 years.
• A person with serious injuries.
• A person diagnosed with coronary artery disease.

How Well It Works

Desmopressin usually will stop bleeding in people who have mild to moderate von Willebrand's disease (type 1). But the drug's effectiveness varies with each individual.

Side Effects

Possible side effects include:

• Fluid retention.
• Mild increase in pulse or blood pressure.
• Redness of the face and neck (flushing).
• Headache.
• Nausea.
• In rare cases, a blood clot in a vein (thrombosis).

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

This medicine:

• May become ineffective if used too often.
• Should be used with caution in people who have a fluid or electrolyte imbalance.
• Is inexpensive compared to clotting factor replacement therapy.

Complete the new medication information form (PDF) (What is a PDF document?) to help you understand this medication.

Author:	Robin Parks, MS	Last Updated: November 24, 2008
Medical Review:	Anne C. Poinier, MD - Internal Medicine Joseph O'Donnell, MD - Hematology/Oncology
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