Procarbazine

Examples

Generic Name	Brand Name
procarbazine	Matulane

Procarbazine is given in pill form.

How It Works

Procarbazine is classified as an alkylating agent. It causes cell death by interfering with the way genetic material (DNA) in the cell multiplies.

Why It Is Used

Procarbazine is used to treat leukemia and non-Hodgkin's lymphoma. It may also be used to treat other kinds of cancer.

How Well It Works

Procarbazine is an effective treatment for non-Hodgkin's lymphoma.

Side Effects

Side effects of procarbazine are common, generally mild, and may include:

• Nausea or vomiting.
• Loss of appetite.
• Mouth sores (stomatitis).
• Changes in the way things taste.
• Cough or shortness of breath.
• Tingling or numbness of fingers or toes (peripheral neuropathy).
• Skin rash, which may itch.
• Diarrhea.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

Procarbazine should be administered only under the supervision of a medical oncologist or hematologist.

Procarbazine can affect your ability to have children. You may not be able to become pregnant or father a child after taking procarbazine. Discuss fertility with your doctor before starting treatment with this medication.

Procarbazine can cause birth defects. Do not use this medication if you are pregnant or wish to become pregnant or father a child while you are taking it.

Women who take this medication may experience menopausal symptoms, including hot flashes and vaginal dryness.

Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.

Author:	Robin Parks, MS	Last Updated: June 12, 2006
Medical Review:	Caroline S. Rhoads, MD - Internal Medicine Douglas A. Stewart, MD - Medical Oncology
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