Rosuvastatin

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Also indexed as:

Crestor

About rosuvastatin

Rosuvastatin is used along with dietary changes to reduce total and LDL ("bad") cholesterol and fat levels in the blood, and to increase HDL ("good") cholesterol levels. It belongs to a class of drugs called HMG-CoA reductase inhibitors.

Overview

Try these helpful products which may be beneficial if taken with this medicine

• CoQ10
• Supplementing with 30 to 100 mg of coenzyme Q10 per day may maintain adequate blood levels of this heart-healthy nutrient

• Cholesterol-lowering margarine
• Using margarines containing sitostanol (Benecol), which is made from pine tree wood pulp and naturally occurring unsaturated sterols obtained from soybean oil (Take Control), can help lower LDL ("bad") cholesterol

These recommendations are not comprehensive and are not intended to replace the advice of your doctor or pharmacist. Continue reading the full article for more information on interactions with vitamins, herbs, and foods.

Herbs

Summary of Interactions for Rosuvastatin

Depletion or interference	None known
Adverse interaction	Pomegranate juice* Red yeast rice Vitamin B3 (niacin)*
Side effect reduction/prevention	None known
Supportive interaction	Sitostanol Vitamin B3 (niacin)
Reduced drug absorption/bioavailability	None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Supplements

Vitamin B3 (niacin)

A recent blinded study showed that individuals taking both rosuvastatin and niacin had a greater increase in HDL ("good") cholesterol and apolipoprotein A-I than did those taking rosuvastatin alone.¹ People taking rosuvastatin might benefit from taking niacin, though they should consult with their healthcare provider before starting the supplement. When taken with niacin, some statin drugs may become more toxic so there is a possibility of an adverse interaction.

Sitostanol

A synthetic molecule related to beta-sitosterol, sitostanol, is available in a special margarine and has been shown to lower cholesterol levels. In one study, supplementing with 1.8 grams of sitostanol per day for six weeks enhanced the cholesterol-lowering effect of various statin drugs.²

Interactions with Herbs

Red yeast rice (Monascus purpureas)

A supplement containing red yeast rice (Cholestin) has been shown to effectively lower cholesterol and triglycerides in people with moderately elevated levels of these blood lipids.³ This extract contains small amounts of naturally occurring HMG-CoA reductase inhibitors such as lovastatin and should not be used if you are currently taking a statin medication.

Other Interactions

Pomegranate juice

In a case report, a man taking rosuvastatin developed severe muscle damage (rhabdomyolysis), a known side effect of rosuvastatin, after he began drinking pomegranate juice (about 6 ounces twice a week). While a cause-effect relationship was not proven, the authors of this report suggested that pomegranate may have increased the toxicity of rosuvastatin by slowing the rate at which the body broke it down.⁴

References

1. Capuzzi DM, Morgan JM, Weiss RJ, et al. Beneficial effects of rosuvastatin alone and in combination with extended-release niacin in patients with a combined hyperlipidemia and low high-density lipoprotein cholesterol levels. Am J Cardiol 2003;91:1304-10.
2. Goldberg AC, Ostlund RE Jr, Bateman JH, et al. Effect of plant stanol tablets on low-density lipoprotein cholesterol lowering in patients on statin drugs. Am J Cardiol 2006;97:376-9.
3. Heber D, Yip I, Ashley JM, et al. Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Am J Clin Nutr 1999;69:231-6.
4. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6.

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Last Review: 01-21-2009

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires February 2010.

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