Glutamic Acid

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Glutamic acid (glutamate) is an amino acid used by the body to build proteins. Glutamate is the most common excitatory (stimulating) neurotransmitter in the central nervous system.

Where is it found?

Sources of glutamic acid include high-protein foods, such as meat, poultry, fish, eggs, and dairy products. Some protein-rich plant foods also supply glutamic acid.

Health Concerns

Glutamic acid has been used in connection with the following conditions (refer to the individual health concern for complete information):

Rating	Health Concerns
	Benign prostatic hyperplasia
	Heart surgery (support)
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. An herb is primarily supported by traditional use, or the herb or supplement has little scientific support and/or minimal health benefit.

Deficiency Symptoms

Who is likely to be deficient?

Most food sources of protein supply glutamic acid, so only a person deficient in protein would become deficient in glutamic acid.¹

Dosage

How much is usually taken?

Healthy people do not need to take glutamic acid as a supplement; for those who do use this amino acid, appropriate amounts should be determined with the consultation of a physician.

Side Effects

Are there any side effects or interactions?

Glutamic acid is generally free of side effects for the vast majority of people who take it; however, people with kidney or liver disease should not consume high intakes of amino acids without consulting a healthcare professional. Because over stimulation of glutamate receptors is thought to be a possible cause of certain neurological diseases (e.g., amyotrophic lateral sclerosis [Lou Gehrig's disease] and epilepsy), people with a neurological disease should consult of physician before supplementing with glutamate.

Monosodium glutamate (MSG), the form of glutamic acid that is used as a flavor enhancer, has been reported in anecdotal studies to have a number of different adverse effects (including headache, fatigue, and depression). However, controlled trials have failed to confirm that MSG causes these side effects, and the safety of this compound remains controversial.

At the time of writing, there were no well-known drug interactions with glutamic acid.

References

1. Zello GA, Wykes LF, Ball RO, et al. Recent advances in methods of assessing dietary amino acid requirements for adult humans. J Nutr 1995;125:2907-15.

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Last Review: 09-01-2007

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