Glucomannan - [Alternative Medicine]

Glucomannan

Alternative Medicine
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Glucomannan is a water-soluble dietary fiber that is derived from konjac root (Amorphophallus konjac). Like other forms of dietary fiber, glucomannan is considered a "bulk-forming laxative." Glucomannan promotes a larger, bulkier stool that passes through the colon more easily and requires less pressure-and subsequently less straining-to expel.

Where is it found?

Glucomannan is a purified fiber from konjac root that is available as a bulk powder to be taken in hard-gelatin capsules or used as an ingredient in food.

Health Concerns

Glucomannan has been used in connection with the following conditions (refer to the individual health concern for complete information):

Rating	Health Concerns
	Constipation High blood cholesterol Insulin resistance syndrome (Syndrome X) Type 2 diabetes
	Obesity
	Diverticular disease Hypoglycemia Type 1 diabetes
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. An herb is primarily supported by traditional use, or the herb or supplement has little scientific support and/or minimal health benefit.

Deficiency Symptoms

Who is likely to be deficient?

As glucomannan is not an essential nutrient, no deficiency state exists.

Dosage

How much is usually taken?

The amount of glucomannan shown to be effective as a laxative is 3-4 grams per day.^1, ² Effective amounts for lowering blood cholesterol have been 4-13 grams per day.^3, ^4, ⁵ For controlling blood sugar, 500-700 mg of glucomannan per 100 calories in the diet has been used successfully in controlled research.^6, ⁷ For weight loss, 1 to 3 grams before each meal has been effective.^8, ⁹ When using glucomannan and other dietary fiber supplements, it is best to start out with a small amount and increase gradually. It is recommended to drink at least 8 ounces of water each time any bulk-forming laxative, including glucomannan, is taken.

Side Effects

Are there any side effects or interactions?

People with any disorder of the esophagus (the tube leading from the mouth to the stomach) should not take any fiber supplement in a pill form, as the supplement may expand in the esophagus and lead to obstruction.¹⁰ Preliminary reports in humans, as well and animal research, suggest that some people may be sensitive to inhaled glucomannan powder.¹¹

Since intestinal bacteria ferment water-soluble fibers, a great deal of intestinal gas may be produced in individuals not accustomed to a high fiber diet, leading to flatulence and abdominal discomfort.

At the time of writing, there were no well-known drug interactions with glucomannan.

References

Marsicano LJ, Berrizbeitia ML, Mondelo A. Use of glucomannan dietary fiber in changes in intestinal habit. G E N 1995;49:7-14 [in Spanish].
Passaretti S, Franzoni M, Comin U. et al. Action of glucomannans on complaints in patients affected with chronic constipation: a multicentric clinical evaluation. Ital J Gastroenterol 1991;23:421-5.
Arvill A, Bodin L. Effect of short-term ingestion of konjac glucomannan on serum cholesterol in healthy men. Am J Clin Nutr 1995;61:585-9.
Vuksan V, Jenkins DJ, Spadafora P, et al. Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes. A randomized controlled metabolic trial. Diabetes Care 1999;22:913-9.
Vuksan V, Sievenpiper JL, Owen R, et al. Beneficial effects of viscous dietary fiber from Konjac-mannan in subjects with the insulin resistance syndrome: results of a controlled metabolic trial. Diabetes Care 2000;23:9-14.
Vuksan V, Jenkins DJ, Spadafora P, et al. Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes. A randomized controlled metabolic trial. Diabetes Care 1999;22:913-9.
Vuksan V, Sievenpiper JL, Owen R, et al. Beneficial effects of viscous dietary fiber from Konjac-mannan in subjects with the insulin resistance syndrome: results of a controlled metabolic trial. Diabetes Care 2000;23:9-14.
Walsh DE, Yaghoubian V, Behforooz A. Effect of glucomannan on obese patients: a clinical study. Int J Obes 1984;8:289-93.
Vita PM, Restelli A, Caspani P, Klinger R. Chronic use of glucomannan in the dietary treatment of severe obesity. Minerva Med 1992;83:135-9 [in Italian].
Henry DA, Mitchell AS, Aylward J, et al. Glucomannan and risk of oesophageal obstruction. Br Med J 1986;292:591-2.
Werley MS, Burleigh-Flayer H, Mount EA, Kotkoskie LA. Respiratory sensitization to konjac flour in guinea pigs. Toxicology 1997;124:115-24.

Last Review: 01-21-2009

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires February 2010.

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