Selegiline

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Also indexed as:

Carbex, Eldepryl

Selegiline is used together with levodopa and carbidopa to treat symptoms of Parkinson's disease.

Herbs

Summary of Interactions for Selegiline

Depletion or interference	None known
Adverse interaction	Ephedra Tyramine
Side effect reduction/prevention	None known
Supportive interaction	5-HTP Food L-Tryptophan
Reduced drug absorption/bioavailability	None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Supplements

L-Tryptophan and 5-HTP

Both L-tryptophan and 5-HTP have been used to treat depression. One controlled study showed that taking selegiline at the same time as 5-HTP enhanced the antidepressant effect when compared with 5-HTP alone.¹ Further research is needed to determine whether taking selegiline and 5-HTP together might result in unwanted side effects.

Interactions with Herbs

Ephedra

Ephedrine is an active ingredient found in ephedra, an herb that until 2004 was used in cold remedies and herbal weight loss products. One individual taking selegiline together with ephedrine experienced a serious side effect known as hypertensive crisis, in which blood pressure can reach dangerous levels.² Though no studies have investigated whether the herb ephedra might result in similar effects, the current evidence suggests that people taking selegiline should avoid all products that contain ephedra.

Other Interactions

Food

Taking selegiline with food dramatically increases the absorption of the drug.³ Problems might occur when individuals switch from taking selegiline with food to taking it on an empty stomach and vice versa. Therefore, people should consistently take selegiline with a meal to enhance the effects of the drug and to avoid problems.

Tyramine-containing Foods

Rarely, people taking selegiline might experience a rapid rise in blood pressure and a severe throbbing headache when the drug is taken with foods that contain tyramine, such as cheese (especially aged); sour cream; yogurt; alcoholic beverages; meat, fish, and poultry; a variety of fruits and vegetables, including avocados, figs, and eggplant; fava beans; some soups; and chocolate.⁴ One study showed that taking 30 mg of selegiline each day greatly increases tyramine sensitivity.⁵ It has therefore been suggested that people taking 30 mg or more of selegiline per day should consume a tyramine-free diet.

References

1. Mendlewicz J, Youdim MB. Antidepressant potentiation of 5-hydroxytryptophan by L-deprenil in affective illness. J Affect Disord 1980;2:137-46.
2. Sifton DW, ed. Physicians' Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 1025-7.
3. Sifton DW, ed. Physicians' Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 1025-7.
4. Sifton DW, ed. Physicians' Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 1025-7.
5. Prasad A, Glover V, Goodwin BL, et al. Enhanced pressor sensitivity to oral tyramine challenge following high dose selegiline treatment. Psychopharmacology (Berl) 1998;95:540-3.

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Last Review: 09-01-2007

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2008.

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