Magnesium Hydroxide

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Also indexed as:

Milk of Magnesia, MOM

Combination List

Combination drugs:

• Advanced Formula Di-Gel Tablets
• Calcium Rich Rolaids
• Co-Magaldrox
• Maalox
• Maalox Plus
• Mylanta
• Tempo Tablets

Magnesium hydroxide is used as an antacid for short-term relief of stomach upset and as a laxative for short-term treatment of constipation. Magnesium hydroxide is available in nonprescription products alone and in combination with other nonprescription ingredients to relieve stomach upset.

Herbs

Summary of Interactions for Magnesium Hydroxide

Depletion or interference	Folic Acid Iron*
Adverse interaction	None known
Side effect reduction/prevention	None known
Supportive interaction	None known
Reduced drug absorption/bioavailability	None known
Other (see text)	Potassium

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Supplements

Folic acid

Folic acid is needed by the body to utilize vitamin B12. Antacids, including magnesium hydroxide, inhibit folic acid absorption.¹ People taking antacids are advised to supplement with folic acid.

Iron

Antacids, including magnesium hydroxide, may reduce the absorption of dietary iron. Iron supplements do not require stomach acid for absorption and one human study found that a magnesium hydroxide/aluminum hydroxide antacid did not decrease supplemental iron absorption.²

Potassium

Individuals taking potassium-depleting diuretics and those who are otherwise at risk of developing potassium deficiency (such as people with chronic diarrhea or vomiting) may experience a fall in serum potassium levels if they take magnesium without taking additional potassium.³ This could lead to muscle cramps or, in individuals taking digoxin or digitalis, more serious problems such as cardiac arrhythmias. Individuals who have a history of potassium deficiency and those who are at risk of developing potassium deficiency, as well as people taking digoxin or digitalis, should consult a physician before taking magnesium-containing products.

References

1. Russell RM, Golner BB, Krasinski SD, et al. Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid. J Lab Clin Med 1988;112:458-63.
2. O'Neil-Cutting MA, Crosby WH. The effect of antacids on the absorption of simultaneously ingested iron. JAMA 1986;255:1468-70.
3. Dyckner T, Wester PO. Ventricular extrasystoles and intracellular electrolytes before and after potassium and magnesium infusions in patients on diuretic treatment. Am Heart J 1979;97:12-8.

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Last Review: 09-01-2007

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2008.

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