Gemfibrozil

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Also indexed as:

Apo-Gemfibrozil, Lopid, Novo-Gemfibrozil

Gemfibrozil is a drug used to lower cholesterol and triglycerides in people with high cholesterol. Other drugs, especially members of the HMG-CoA reductase inhibitor drug family, are more commonly used.

Herbs

Summary of Interactions for Gemfibrozil

Depletion or interference	Coenzyme Q10* Vitamin E*
Adverse interaction	Red yeast rice*
Side effect reduction/prevention	None known
Supportive interaction	Vitamin B3 (niacin)
Reduced drug absorption/bioavailability	None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Supplements

Coenzyme Q10

In a randomized study of 21 men with combined hyperlipidemia, ten to twelve weeks of gemfibrozil therapy reduced coenzyme Q10 blood levels to the levels seen in healthy men.¹ The clinical significance of this finding is unknown.

Vitamin E

In a randomized study of 21 men with combined hyperlipidemia, ten to twelve weeks of gemfibrozil therapy reduced alpha- and gamma-tocopherol blood levels to the levels seen in healthy men.² The clinical significance of this finding is unknown and may reflect a normal physiological response to a reduction in serum cholesterol levels.

Vitamin B3 (Niacin)

Niacin (not niacinamide) and gemfibrozil have successfully raised HDL (good) cholesterol levels, both alone and in combination.³

Interactions with Herbs

Red yeast rice (Monascus purpureus)

Monascus purpureus, a form of red yeast, is fermented with rice to produce a dietary supplement, Cholestin®, that contains low levels of lovastatin, a drug otherwise available only by prescription. Gemfibrozil taken with the prescription drug lovastatin has been reported to cause rhabdomyolysis, a potentially life-threatening muscle disease.⁴ People taking gemfibrozil should avoid lovastatin-containing products, including Cholestin®, until more is known. The levels of lovastatin in Cholestin® are significantly lower than those given of the drug as a single agent. Cholestin® also contains numerous other compounds that may alter the interaction of lovastatin and gemfibrozil.

Other Interactions

Food

Gemfibrozil should be taken 30 minutes before meals.⁵

Alcohol

Gemfibrozil may cause dizziness or blurred vision.⁶ Alcohol may intensify these effects, increasing the risk for accidental injury. People taking gemfibrozil should avoid alcohol.

References

1. Aberg F, Appelkvist EL, Broijersen A, et al. Gemfibrozil-induced decrease in serum ubiquinone and alpha- and gamma-tocopherol levels in men with combined hyperlipidaemia. Eur J Clin Invest 1998;28:235-42.
2. Aberg F, Appelkvist EL, Broijersen A, et al. Gemfibrozil-induced decrease in serum ubiquinone and alpha- and gamma-tocopherol levels in men with combined hyperlipidaemia. Eur J Clin Invest 1998;28:235-42.
3. Zema MJ. Gemfibrozil, nicotinic acid and combination therapy in patients with isolated hypoalphalipoproteinemia: a randomized, open-label, crossover study. J Am Coll Cardiol 2000;35:640-6.
4. Garnett WR. Interactions with hydroxymethylglutaryl-coenzyme A reductase inhibitors. Am J Health Syst Pharm 1995;52:1639-45 [review].
5. Threlkeld DS, ed. Diuretics and Cardiovasculars, Antihyperlipidemic Agents, Gemfibrozil. In Facts and Comparisons Drug Information. St. Louis, MO, Facts and Comparisons, Feb 1997, 172h-2j.
6. Threlkeld DS, ed. Diuretics and Cardiovasculars, Antihyperlipidemic Agents, Gemfibrozil. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1997, 172h-2j.

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Last Review: 01-21-2009

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires February 2010.

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