Fexofenadine

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Also indexed as:

Allegra

Combination List

Combination drug:

• Allegra-D

Fexofenadine is a selective antihistamine used to relieve seasonal allergies (allergic rhinitis) symptoms including sneezing, runny nose, itching, and watery eyes. Fexofenadine is available alone and in a combination product.

Herbs

Summary of Interactions for Fexofenadine

Depletion or interference	None known
Adverse interaction	Grapefruit, orange, or apple juices Pomegranate juice*
Side effect reduction/prevention	None known
Supportive interaction	None known
Reduced drug absorption/bioavailability	None known
Other (see text)	St. John's wort

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Herbs

St. John's Wort

In a study of healthy volunteers, administration of 900 mg of St. John's wort one hour prior to fexofenadine resulted in a significant increase in blood levels of fexofenadine, compared with the blood levels after taking fexofenadine alone.¹ On the other hand, long-term administration of St. John's wort (300 mg three times per day for two weeks) did not alter blood levels of fexofenadine. Until more is known, St. John's wort should not be combined with fexofenadine, except under the supervision of a doctor.

Other Interactions

Juices

Drinking grapefruit juice, orange juice, or apple juice with fexofenadine decreases blood levels of the drug.^{2, 3}

Pomegranate juice

Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice.^{4, 5} The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with fexofenadine in the same way that grapefruit juice does.

Alcohol

Selective antihistamines, including fexofenadine, may cause drowsiness or dizziness; however, it is less likely than with nonselective antihistamines.⁶ Alcohol can intensify drowsiness and dizziness, increasing the risk of accidental injury.

References

1. Wang Z, Hamman MA, Huang SM, et al. Effect of St John's wort on the pharmacokinetics of fexofenadine. Clin Pharmacol Ther 2002;71:414-20.
2. Dresser GK, Bailey DG, Leake BF, et al. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharmacol Ther 2002;71:11-20.
3. Dresser GK, Kim RB, Bailey DG. Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides. Clin Pharmacol Ther 2005;77:170-7.
4. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6.
5. Summers KM. Potential drug-food interactions with pomegranate juice. Ann Pharmacother 2006;40:1472-3.
6. Threlkeld DS, ed. Respiratory Drugs, Antihistamines. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1998, 194c.

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Last Review: 09-01-2007

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