Clofibrate

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Also indexed as:

Atromid-S

Clofibrate is a drug used to lower cholesterol in people with high blood cholesterol. It is rarely used, due to the possibility of liver damage and the availability of safer, more effective drugs.

Herbs

Summary of Interactions for Clofibrate

Depletion or interference	Vitamin B12*
Adverse interaction	None known
Side effect reduction/prevention	Milk thistle*
Supportive interaction	None known
Reduced drug absorption/bioavailability	None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Supplements

Vitamin B12

Clofibrate has been reported to reduce absorption of vitamin B12.¹

Interactions with Herbs

Milk thistle(Silibum marianum)

Although there have been no clinical studies, use of milk thistle with clofibrate may theoretically lower the risk of liver side effects associated with the drug. People may take a standardized milk thistle extract supplying 70-80% silymarin at an amount of 200 mg three times per day.

References

1. Robinson C, Weigly E. Basic Nutrition and Diet Therapy. New York: Macmillan, 1984, 46-54.

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Last Review: 01-21-2009

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires February 2010.

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